The treatment of Toxoplasma gondii (T. gondii) infection 
accentuates the problem of the limited effectiveness of the 
available anti-parasitic agents and their side effects and also, 
the potential appearance of resistant Toxoplasma strains. 
Thus, the search of the newer and more effective drugs is 
needed. This study aimed to review the efficacy of some 
herbal plants extracts on T. gondii infection, in an attempt to 
overcome the side effects of hazardous drugs. It was found 
that many herbal plants extracts exhibit anti-Toxoplasma 
activity including Nigella sativa, Zingiber officinale, Myrrh, 
Piper nigrum, Capsicum frutescens, Curcuma longa, 
Azadirachta indica (neem) and Melia azedarach. However, 
their efficacies in human toxoplasmosis remain to be 
confirmed in clinical trials. The use of such medicinal plants 
extracts has a more beneficial effect in prophylaxis as well as 
treatment of this protozoan infection through being safer, 
acceptable, affordable, culturally compatible, widely 
available at low cost and suitable for treatment of chronic 
toxoplasmosis.