Open Access Research

Articles

Browse published and in-press articles from all Aperito Publishing journals.

Latest Articles

Browse Journals

The Roles of Microenvironment in Tumor Dormancy

Several studies have shown that metastatic cancer cells may lie dormant in a secondary site for more than a decade, all the while retaining the ability to aggressively reemerge. Once these dormant cancer cells ...

View Article PDF

The Cities with Inhabitants which Suffering from Dental Fluorosis, Is the Drinking Water the Only Reason? Epidemiologic Report

The most cities which their inhabitants are suffering from fluorosis, located in plain regions or margins of seas. However; there are some other cities located in high and mountainous regions with high prevalen...

View Article PDF

Unilateral Anemic Retinopathy Mimicking Central Vein Occlusion in a Patient with Menorrhagia

Unilateral anemic retinopathy is an uncommon but reversible condition. A 43-year-old female presented with right eye blurring of vision for one week duration. She also had menorrhagia for a year. Examination showed ...

View Article PDF

Cardiac Remodeling with Excessive Visceral Adiposity beyond Anthropometrics in Asymptomatic Asians

Purpose: Visceral Adipose Tissue (VAT) as a source of proinflammatory and biological mediators is implicated in adverse cardiac structure remodeling, functional alternations, and results in Heart Failure (HF) in cen...

View Article PDF

Sigmund Freud’s Maxillary Jawbone Cancer (1856-1939)

From 1919 to his death, Sigmund Freud was treated for a maxillary jawbone cancer by two exceptional surgeons, the Austrian, Hans Pichler, and the American, Varaztad Kazanjian. Escaping the Nazi regime, he went into ...

View Article PDF

Bilateral Exudative Macula Detachment in a Mother with Pre-Eclampsia: Case Report and Review of Literature Md-Said Haslinda1, Li Min Evelyn-Tai1, Hussein Adil1, Nik Lah Nik-Ahmad-Zuky2 and Ismail Shatriah1*

Generalised exudative retinal detachment, choroidal infarction and cortical blindness are known visual threatening conditions in patients with pre-eclampsia/eclampsia. Localised macula detachment is an uncommon ocul...

View Article PDF

Orbital Manifestation of Langerhans Cell Histiocytosis in a Child - A Diagnostic Dilemma

Langerhans Cell Histiocytosis (LCH) is a rare and variable disease process that mimics inflammatory and sometimes malignant disease. Diagnosis is challenging as it may simulate abscess, hematoma, acute dacryocystiti...

View Article PDF

Urethritis due to Multiple Sexually-transmitted Infection Agents in a Young Male in Turkey

Sexually Transmitted Diseases (STDs) are caused by a large number of microorganisms mostly with Chlamydia trachomatis and Neisseria gonorrhoeae. Data concerning the frequency of STD agents is scarce in the Islamic W...

View Article PDF DOI: 10.14437

Corneal Fungal Keratomycosis - A Therapeutic Challenge: A Case Report

Objective: To report a case of fungal keratitis caused by Fusarium species. Result: A 57 year old man presented with painful blurring of vision of his left eye. There was presence of dry corneal ulcer with irre...

View Article PDF

Subclinical Behcet’s Disease

Behcet’s Disease (BD) is a chronic inflammatory multisystem disease belongs to the Vasculitidies with small, medium and large sized vessel involvement. This disorder is characterized by Oral aphthosis, Genital...

View Article PDF

“2016 Novel Guideline” Approaching Towards Joint Pain

In the history of the patient with joint pain we have to know whether or not the joint pain is mechanical or inflammatory, acute or chronic and traumatic or non-traumatic. In the physical examination of the patient,...

View Article PDF

Effectiveness of RDT and Microscopy in Detection of Malaria Parasite

Malaria presents a diagnostic challenge to laboratories especially in non-endemic malaria countries. Population movements and Travellers all contribute to presenting the laboratory with diagnostic problems for which it may have li...

View Article PDF DOI: 10.14437

Plasmacytoma in TMJ Region

Plasmacytoma is a rare malignant disease based of differentiated plasmatic B cells, which occurs also in the head and neck region. It rarely involves the mandible. The authors present an unusual evaluation of this p...

View Article PDF DOI: 10.14437

Clinical Factors Associated with Musculoskeletal Injuries in Children and Adolescents with Diabetes Mellitus

Background: To examine the incidence of traumatic and overuse Musculoskeletal Injuries (MSI) in children and adolescents with diagnosed diabetes mellitus, which has been understudied. Methods: Using a population-bas...

View Article PDF

Biogas Upgrading Technologies: A Mini-Review

Biogas production is growing nowadays due to the increasing installation of anaerobic digesters for organic waste treatment, mainly in Europe, promoted by the current environmental legislation. Depending on the final use, differen...

View Article PDF

Pre-Ankylosing Spondylitis State

Ankylosing Spondylitis (AS) is a chronic inflammatory systemic disorder belonging to the SpondyloArthridies with axial joint involvement and enthesitis, with or without peripheral arthritis and systemic involvement....

View Article PDF

Solitary Osteochondroma of Dorsal Spine – A Rare Case Report

Osteochondroma or bony exostosis is a common benign tumor of bone occurring predominantly in long bones. It may arise infrequently from the spine giving rise to vague symptoms as backache or may lead to compressive ...

View Article PDF DOI: 10.14437

Cranial Nerve Palsy as the Most Common Presentation of Neuro Ophthalmic Conditions at Hospital Universiti Sains Malaysia – An 8 Year Review

Objective: To review cranial nerve palsy as the most common presentation of neuro-ophthalmic conditions presenting to Ophthalmology Clinic, Hospital Universiti Sains Malaysia, Kelantan. Methods: Retrospective c...

View Article PDF

Common Celiacomesenteric Trunk Originating from Aorta Involved in Atherosclerotic Occlusion Menifested as Acute on Chronic Mesenteric Ischemia

60 year old male patient was admitted with acute on chronic mesenteric ischeamia. He was found to have rare anatomical variant of common celiacomesenteric trunk which had atherosclerotic occlusive disease. Revascula...

View Article PDF

Assessment of Divalent Metal-Toxicity and the Role of 24 Epibrassinolide in Triticum Aestivum Seedlings

Reports on the metal-toxicity are extensive; however, literature is scarce on the role of sustainable stress-mitigation approaches in this context. This work investigated the significance of growth regulator 24-epibrassinolide (24...

View Article PDF DOI: 10.14437

Design for an Intelligent BIM Based Energy Management System

Building information modeling (BIM), it means a digital simulation of buildings with real information. Information connotation of just geometry description also contains a large number of non-geometric properties of...

View Article PDF DOI: 10.14437

Is Cold Water Gargling Effective in Treating Postoperative Nausea and Vomiting?

Purpose: Recently, a multimodal strategy using various medications and non-pharmacological methods has been recommended for treating Postoperative Nausea and Vomiting (PONV). Cold water gargling may be helpful as on...

View Article PDF DOI: 10.14437

Computer Vision Methodology for Structural Health Monitoring

Currently, the security of large civil engineering structures more and more people's attention, health monitoring study civil engineering at home and abroad is one of the hot topics of research. After a hundred year...

View Article PDF DOI: 10.14437

Prevalence of Visual Acuity Disorders among Intermediate School Students in Riyadh, Saudi Arabia

Our objectives in this study are to determine the prevalence of visual acuity disorders and to identify the important risk factors that associated with visual acuity disorders among Intermediate school students in R...

View Article PDF

qRT-PCR is a Highly Sensitive, Highly Specific Diagnostic Adjunct to H&E Microscopy to Detect Giardia Using Formalin-Fixed Paraffin-Embedded Tissue

Background: The diagnosis of Giardia spp. may pose a challenge on routine Haematoxylin and Eosin (H&E) sections of small intestinal biopsy specimens. Additionally, clinicians may not order additional laboratory ...

View Article PDF DOI: 10.14437

Gastric Polypoid Lymphoma of Mucosa-Associated Lymphoid Tissue Type

A polypoid, or submucosal tumor-like, presentation of Mucosa-Associated Lymphoid Tissue (MALT) lymphoma is relatively rare, while correct clinical and histopathological diagnoses of such cases are important for pati...

View Article PDF DOI: 10.14437

Dental Caries Experience among 15 Year Old School Children from Macedonia and India

Aim: The aim of the present study was to compare the dental caries status of the 15 year old children of the southeast region of Macedonia and Bandipora District of Kashmir Division of Jammu and Kashmir State of Ind...

View Article PDF

Design of Two-Wheeled Ultrasonic Wheel

Design of two-wheeled ultrasonic wheel is proposed for applications in micro-stepping displacement devices. The ultrasonic wheel includes a beam and two displacement members which are respectively pivoted on the bea...

View Article PDF DOI: 10.14437

Recalcitrant Pyoderma Gangrenosum- Like Atypical Mycobacterial Infection Successfully Treated with Combination of First and Second Line Anti Tubercular Drugs

A 65-year-old male presented in the outpatient department with multiple painful ulcers and pustules on the whole trunk. The total duration of disease was 14-months. He was provisionally diagnosed as a case of pyoder...

View Article PDF DOI: 10.14437

Ameliorative Effect of Glycyrrhizic Acid against Doxorubicin-Induced Cardiotoxicity in Rats

Doxorubicin (DOX) is a potent anticancer drug whose application is hampered by its cardiotoxicity mediated by oxidative stress and inflammation.  Glycyrrhizic acid (glycyrrhizin) is a natural compound that exer...

View Article PDF DOI: 10.14437

Anti-Parasitic Activity of Zingiber officinale (Ginger): A Brief Review

Zingiber officinale (Z. officinale) is a perennial herb with several medicinal properties. Development of modern drugs from Z. officinale can be emphasized for the control of various diseases. The feasibility of usi...

View Article PDF DOI: 10.14437

TEE Guided Surgical Treatment in Active Infective Endocarditis: Results of a Single Centre Four Year Experience

Background: Recently developed strategies (valve repair, homograft implantation) may improve clinical outcome in surgical treatment of infective endocarditis. Careful TEE examination may allow to choice the proper s...

View Article PDF DOI: 10.14437

In Three Cases, the Use of Dabigatran was Found to be Associated with Factor VIII Inhibitors and Prolonged APTT

We report the use of dabigatran was found to be associated with Factor VIII inhibitors and prolonged APTT in the three cases. Taking the dabigatran was recognized prolonged APTT, low titer Factor Ⅷ inhibitors and ...

View Article PDF DOI: 10.14437

Molecular Identification of the Most Prevalent Mutations of the Glucose-6-Posphate Dehydrogenase (G6PD) Gene in Deficient Egyptian Patients

Introduction Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is a common human enzyme deficiency. Molecular abnormalities data from Egypt are scarce, and have not been extensively investigated. To fill this...

View Article PDF DOI: 10.14437

Self-reported of Oral Hygiene Knowledge & Attitude among Iranian Prenatal Women: A Single Center Experience

Background: Pregnant women are more susceptible to periodontal disease and it may be associated with adverse pregnancy outcomes. Objectives: The objectives of this study were to assess women’s knowledge a...

View Article PDF

The Association between Three-Dimensional Pericardial Adiposity Measures, Life Quality Scores and Physical Functional Status beyond Anthropometrics in Men

Background: Previous studies demonstrated visceral adiposity in relation to metabolic disorder may mediate systemic inflammation and predict cardiovascular outcomes. However, data regarding visceral adipose tissue b...

View Article PDF

Schistosomiasis: An Association with Autoimmunity

The association between Schistosomes infection and autoimmunity has been studied extensively in the medical literature. Schistosomiasis might induce autoimmune activity by several mechanisms: molecular mimicry, prod...

View Article PDF

Parotid Saliva Secretion by Mechanical Stimulation is Site Specific in the Oral Cavity in Human Subjects

For oral health, it is an important issue to keep and, if deteriorated, to improve salivary secretion. Although mechanical stimulation in chewing and masticating bolus induces the salivary secretion, it is not ...

View Article PDF

Synthesis of Bioactive Glass and its Antibacterial Effect on Mupirocin Resistant, Methicillin-Resistant Staphylococcus Aureus

Rapid resistance to mupirocin occurs among strains of Methicillin-Resistant Staphylococcus Aureus (MRSA) which the main etiological agent is causing community-acquired and hospital-acquired infections. Powdered...

View Article PDF DOI: 10.14437

Retinal Primary Benign Tumor with Unusual Histopathological Exam

Purpose: To describe a new subtype of retinal tumor. Conclusion: To the authors’ knowledge, we report a case of benign retinal tumor not previously described, that seemed a vasoproliferative tumor but with unu...

View Article PDF DOI: 10.14437

Recent Updates in Transfusion Transmitted Parasitic Diseases

A number of parasitic diseases have been reported to be transmitted by blood transfusion, including malaria, leishmaniasis, Chagas' disease, babesiosis, toxoplasmosis and filariasis. Majority of blood banks do not s...

View Article PDF DOI: 10.14437

Perspectives of Canadian Healthcare Professionals on Diabetes Self-Management and Care: Diabetes Attitudes, Wishes and Needs 2 (DAWN2™)

Aim: The second Diabetes Attitudes, Wishes and Needs (DAWN2) study aimed to describe the psychosocial challenges faced by People With Diabetes (PWD), their families, and the Healthcare Professionals (HCPs); and to&n...

View Article PDF

Psychosocial and Management Experiences of Canadian Family Members Living with People with Diabetes: The Second Diabetes Attitudes, Wishes and Needs Study (DAWN2™)

Aim: To explore the psychosocial impacts, needs and wishes of Canadian Family Members (FMs) of People With Diabetes (PWD), as part of the second global Diabetes Attitudes, Wishes and Needs (DAWN2™) study. &nbs...

View Article PDF

Successful and Rapid Treatment of Two Patients with Bacillary Angiomatosis with Azithromycin

We report on two homeless, HIV-infected patients with intravenous drug abuse developing a generalized rash composed of angiomatous papules. Based on the clinical manifestations, routine histology and sequencing of&n...

View Article PDF DOI: 10.14437

Congenital Cytomegalovirus Infection in Pregnancy

CytoMegaloVirus (CMV) is an enveloped double stranded DNA virus that belongs to Herpesviridae family. Most of the CMV infections during pregnancy are asymptomatic; but cause congenital malformations in fetus. T...

View Article PDF DOI: 10.14437

The Effect of Eplerenone on Circulating Microparticle Numbers in Patients with Chronic Heart Failure

The study aim was to evaluate whether the Mineralocorticoid Receptors (MR) antagonist eplerenone, effects circulating microparticles originated from apoptotic and activated endothelial cells (EMP) in Chronic Heart&n...

View Article PDF DOI: 10.14437

Tinea Pedis

Tinea pedis, also known as "athlete foot", refers to a superficial fungal infection of the feet caused predominately by dermatophytes. Tinea pedis is most often caused by Trichphyton rubrum and T. interdigitale.&nbs...

View Article PDF DOI: 10.14437

Digital Mucous Cyst

Digital mucous cysts are benign, cystic lesions of the digits typically located near the distal interphalangeal joints or near the proximal nail folds. The peak incidence rates are in the age group between 40 and 70...

View Article PDF DOI: 10.14437

Cardiovascular Collapse in Three-Toed Drongos After Exposure to Atonal Acoustics

This study demonstrates that prolonged exposure of drongos to repetitive auditory stimuli causes sustained increased levels of hypertension, which may explain observations in the local habitat. 

View Article PDF DOI: 10.14437

Diabetes Mellitus: A Potential Risk for Developing Cancer

Epidemiological studies have clearly indicated diabetes as a risk factor for cancer initiation and progression. Both diabetes and cancer are influenced by multiple factors of known and unknown origin. The magni...

View Article PDF

Carotid Intima-Medial Thickness in Diagnosis and Prognosis of Atherosclerotic Risk in Obstructive Sleep Apnea Patients

Obstructive Sleep Apnea (OSA) is associated with accelerated atherosclerosis, cardiovascular and cerebrovascular disease. Carotid artery Intima-Medial Thickness (CIMT) measurement has recently evolved as an imp...

View Article PDF DOI: 10.14437

Non Pharmacological Management of Cyanotic Spell in a Child with Tetralogy of Fallot Undergoing Noncardiac Surgery: A Case Report

Patient with Tetralogy of Fallot (TOF) may sometimes present for noncardiac surgery. These patients may have lots of other congenital anomalies, which may need repeated surgeries for their correction. Anaesthetic&nb...

View Article PDF DOI: 10.14437

Refractory Hypotension Following Sublingual Isosorbide Dinitrate in the Postoperative Period in a Patient with Ischaemic Heart Disease

Anaesthetic management of patients with ischaemic heart disease for noncardiac surgery can be associated with many cardiovascular complications. Sublingual isosorbide dinitrate remains one of the mainstays of m...

View Article PDF DOI: 10.14437

Forensic Aspects of Ocular Trauma

Introduction: Sometimes, in cases of ocular trauma, the ophthalmologist must provide forensic evidence showing the status of the victim, and this requires a detailed eye examination, including an accurate descriptio...

View Article PDF DOI: 10.14437

Prognosis with Proton Pump Inhibitor Versus H2 Blocker Therapy in Clostridium Difficile Infection

An 83-year-old female patient recovered from her primary Clostridium difficile-associated colitis upon antibiotic treatment and the suspension of her regular Proton Pump Inhibitor (PPI) therapy, and had a recurrence...

View Article PDF DOI: 10.14437

Conjunctival Leiomyosarcoma

A 60-year-old lady presented with a fleshy mass at the nasal limbus of the right eye of two months’ duration which was progressively increase in size. Right eye examinations showed a fleshy exophytic mass aris...

View Article PDF DOI: 10.14437

The Association between Cataract Surgery and Cognitive Dysfunction in Cataract Patients - A Population-Based Follow Up in Taiwan

Purpose: Senile cataract and cognitive dysfunction (senile dementia, cognitive impairment and Alzheimer disease) are commonly coexisting. Some ophthalmologists believe that cataract surgery not only&n...

View Article PDF DOI: 10.14437

Diagnosis of Trigeminal Neuralgia: A New Appraisal Based on Response to Treatment

Background: The aim of this study is to evaluate the use of carbamazepine as primary definitive diagnostic aid in patients with classical/idiopathic and symptomatic/ pathological trigeminal neuralgia by analyzing th...

View Article PDF

Surgical Treatment of Hypertrophy with Weakening of Superior Rectus Muscle Function in the Ophthalmology Clinic, University Clinical Centre of Kosovo, Prishtina 2012-2013

Strabismus is a deviation of the eyes, when both eyes simultaneously cannot be directed at the object which is observed [1]. Strabismus occurs in about 2% of children under 3 years old and about 3% of all children&n...

View Article PDF DOI: 10.14437

A North Indian Study of Community Acquired Acute Kidney Injury and its Outcome in Relation to Etiology and Management

Background: Community acquired Acute Kidney Injury (AKI) is more common in developing countries as compared to developed countries. Understanding of the epidemiology of community acquired AKI and its outcome wi...

View Article PDF DOI: 10.14437

Recent Advances in LINE-1 Retrotransposon Biology in the Brain

It is now widely recognized that retrotransposons such as Long Interspersed Element-1 (LINE1 or L1s) have played an instrumental role in shaping the structure and function of our genomes. L1s contribute to ~17% of t...

View Article PDF DOI: 10.14437

Isolated Intracranial Relapse of Acute Myelocytic Leukemia (AML) Following 4 and 1/2 Years of Complete Remission

A seven year old Hispanic girl developed headache, backache and vomiting. A computed tomography showed 2 intracranial masses. A complete blood count was normal. Bone marrow aspiration showed hypoplastic but otherwis...

View Article PDF DOI: 10.14437

Crocus Sativus Linn: An Informative Review

Saffron, Crocus Sativus L. is a perennial bulbous herb. The plant has been priced since antiquity for its yellow orange coloured tripartite stigmas that constitute the Saffron. Also known as saffron crocus, the odour of saffron is...

View Article PDF DOI: 10.14437

Oral Manifestation of Lead Poisoning

Lead was a key component in the medical sciences during its early days. Over the years the toxic effects of lead has been studied in detail and have been withdrawn from the modern drugs. However lead ingestion ...

View Article PDF

Evaluation of Analgesic Efficacy of Transcutaneous Electrical Nerve Stimulation in Acute and Chronic Pain: A Prospective Audit

Introduction: Transcutaneous Electrical Nerve Stimulation (TENS) has been shown to be successful in treating acute as well as chronic pain. But, it has been greatly underused especially for acute pain...

View Article PDF DOI: 10.14437

Differentiation between Complex Tic and Eyelid Myoclonia with Absences: Pediatric Case Report and Brief Review of the Literature

Eyelid Myoclonia with Absences (EMA) can often be clinically mistaken for a tic disorder. This case report describes a 4-year-old female who presented with eye fluttering and blinking accompanied by a hand gesture&n...

View Article PDF DOI: 10.14437

Molecular Mechanisms of Cold Adaptation in Bacteria

Bacteria are ubiquitous in nature and have the ability to survive in severe conditions of low temperature, high pressure and often changing osmotic environment. However, mechanisms of survival of bacteria in extreme...

View Article PDF DOI: 10.14437

Tooth Mortality in Two US Populations Living a Century Apart

Purpose: To determine the frequency of tooth loss of individuals who lived during the nineteenth century and compare it to the current prevalence of tooth loss of an adult population in the US. Materials and Me...

View Article PDF

Perceptions and Acceptability of Male Circumcision in South Africa

Background: The aim of this study was to determine the perceptions and acceptability of male circumcision among the young, as well as older men and women in South Africa. Methods: A total of eleven (11) focus g...

View Article PDF DOI: 10.14437

Pregnancy in Patients with SLE

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease predominantly affecting women of childbearing age. Pregnancy in women with SLE is associated with higher fetal and maternal risk compared with...

View Article PDF

Number of Primary Care Visits Associated with Screening for Cervical Dysplasia among Women with HIV Infection in Harris County, Texas, United States of America

 Studies indicate that women with HIV infection in the United States are inadequately screened for cervical dysplasia. However, few of these studies have included women in the southern United States, where HIV ...

View Article PDF DOI: 10.14437

The Relation to Effective Communication on Cancer among Patients and the Families on Psychological Adaptation between Japanese Chemotherapy-Treated Outpatients and their Family Members

Objective: The purpose of this study was to determine if psychological adaptation between cancer patients and their families is dependent on effectiveness of their communication related...

View Article PDF DOI: 10.14437

5-α-Reductase Deficiency Syndrome: An Experience from a Referral Hospital, Riyadh, Saudi Arabia

Background: 5-α-ReDuctase (5ARD) deficiency, is an autosomal recessive diseases, resulting in the inability to produce the physiologically active DiHydroTestosterone (DHT) which is required for normal viriliza...

View Article PDF DOI: 10.14437

Oral Presentation in Dengue

Dengue is an important mosquito borne viral infection. The classical presentation of dengue is acute febrile illness with hemorrhagic complication. Focusing on oral manifestation, it is not common. In this brief&nbs...

View Article PDF

Diagnostic Delay in Oral Cancer: An Overview of Different Perspectives on a Public Health Problem

Early diagnosis in oral cancer may have a major role in improving survival rates, allowing patients to take advantage of less aggressive treatments, mitigating the morbidity of the process. Definitive diagnosis of o...

View Article PDF

Circadian Rhythm and Cataract Surgery

The circadian rhythm is a complex biologic phenomenon in which environmental light is a major exogenous regulator. Cataract patients’ optical system precludes optimal transmission of light, especially the&nbsp...

View Article PDF DOI: 10.14437

Intracardıac Thrombus Treated Non-Invasively by Antıcoagulant Therapy in a Chıld with Tay-Sachs Disease

We presented a four-year-old girl with Tay-Sachs disease who had thrombus in the right atrium. The patient was admitted to hospital with cardiopulmonary arrest and aspiration pneumonia was diagnosed. Intracardi...

View Article PDF DOI: 10.14437

1, 5-Anhydroglucitol as Marker of Short-Term Hyperglycemic Excursions in Well-Controlled Type 2 Diabetes Mellitus: Associations with the Prevalence of Vascular Complications

Background: Intermittent states of hyperglycemia have been identified as risk factor for vascular complications of type 2 diabetes mellitus independent from the mean blood glucose level. 1,5-Anhydroglucitol (1,5-AG)...

View Article PDF

A Compliance by Australasian Paediatricians with the 2009 NASPGHAN-ESPGHAN Guideline for the Diagnosis and Management of Gastro-Oesophageal Reflux in Children

Objective: To investigate the current approach of Australia and New Zealand paediatricians to children with gastrooesophageal reflux symptoms, comparing practice against the NASPGHAN-ESPGHAN guideline. Method: Prosp...

View Article PDF

Representing a Novel Model of Diet-Induced, Inherited Insulin Resistance and Obesity, Atp10c Heterozygous Mice Show Alterations in Glucose Uptake via both Insulin-Dependent and Non-Dependent Pathways

Diet-Induced Obesity (DIO) is a major risk factor for a number of disorders including non-insulindependent Type 2 Diabetes Mellitus (T2D). In our novel mouse model, the gene Atp10c is a strong candidate for metaboli...

View Article PDF

Computationally Designed Prodrugs Based On Enzyme Models

The striking efficiency of enzyme catalysis has inspired many organic chemists to explore enzyme mechanism(s) by studying certain intramolecular processes (enzyme models) which proceed faster than their intermo...

View Article PDF DOI: 10.14437

A Rare Cause of Haematemesis; a Primary Aorto-Esophageal Fistula: Case Report and Review of Literature

Aorto-Esophageal fistula is a rare condition, causes excessive bleeding from the upper gastrointestinal tract and is associated with a high mortality. This case report demonstrates the presentation of a 63-year old ...

View Article PDF

A Left Asymptomatic Supraclavicular Cystic Mass

A – 19 year – old men was reffered to our Surgical department with a 4 – month history of an asymptomatic swelling in the left supraclavicular fossa. The patient a few months ago, carried sacks of ...

View Article PDF DOI: 10.14437

Measured Anthropometrics are Needed in Rural Areas: An Important Role for School Nurses

In a sample of 8th and 11th grade children at one rural school located in Oregon, USA we demonstrate that measured anthropometric values are needed for accurate surveillance of body mass index (BMI). Gender and&nbsp...

View Article PDF DOI: 10.14437

A Novel Approach for the Management of Diabetes Mellitus

Recent research has shown that there is a link between metabolic diseases (like diabetes, obesity and cardiovascular diseases) and bacterial population in the gut. The results of such studies indicate that Type 2&nb...

View Article PDF

No Differences in Number and Distribution of Dermal Mast Cells between Acute and Chronic Cutaneous Lupus Erythematosus

The appearance of mast cells at eruption sites was examined in acute (ACLE) and chronic (CCLE) cutaneous Lupus Erythematosus (LE). As shown by toluidine blue staining and c-kit immunostaining, mast cells were signif...

View Article PDF

A Missed Opportunity: Indicator Disease Guided Testing for HIV

We report on a 42 year old, heterosexual black man presenting with an anal ulceration and generalized itch. Upon inspection, hyper pigmented disseminated cutaneous patches, non-removable whitish parallel&n...

View Article PDF DOI: 10.14437

Invasive Listeriosis-Atypical Presentation with Delayed Diagnosis

Invasive listeriosis with brain infection remains a diagnostic challenge with an early treatment need to reduce morbidity and mortality. Not only is a foodborne pathogen with a rising incidence but also responsible ...

View Article PDF DOI: 10.14437

The Association between Serum under carboxylated Osteocalcin Level and Type-2 Diabetes Mellitus: Results from the Kyushu and Okinawa Population Study

Objectives: Diabetes can affect bone via obesity, hyperglycemia, hyperinsulinemia, and hypoinsulinemia. Osteocalcin (OC) is a non-collagenous protein of the bone that contributes to bone formation. A population-base...

View Article PDF DOI: 10.14437

Axis-I Diagnosis in Vitiligo and Chronic Urticaria Patients

Background: There is a significant co-morbidity between dermatological disorders and psychiatric. It has been estimated that in at least one-third of patients with skin diseases, their effective manag...

View Article PDF DOI: 10.14437

Prevalence of Chronic Kidney Disease in Unselected Swedish Patients with Type 2 Diabetes and its Association with Cardiovascular Disease

Aim: To estimate the prevalence of Chronic Kidney Disease (CKD) and albuminuria and its associations to prevalent cardiovascular co-morbidities in patients with type 2 diabetes in a primary care setting in Sweden. &...

View Article PDF

Effects of Group B Soyasaponins and Soyasapogenol B on Plasma Cholesterol Levels in Golden Syrian Hamsters

Elevated blood cholesterol levels are associated with the development of heart disease. Group B soyasaponins have been suggested as a factor capable of decreasing plasma lipid concentrations. Soyasaponins are naturally occurring t...

View Article PDF DOI: 10.14437

BK Virus Detection by PCR in Renal Biopsy Specimens from Renal Transplant Patients

Background: BK virus (BKV) infection in renal transplant patients is a constant concern. As BK-induced nephritis may lead to graft failure, detection of the virus is of significant clinical importance. While the dia...

View Article PDF DOI: 10.14437

Establishing and Validation of Modified CRE/Loxp System Useful In Temporal and Spatial Control of Genetic Knocking Out Using In Vitro Approaches by Induced Alpha Complementation

DNA recombinases are used to manipulate the genomic structure and to control the genetic expression in all living organisms. Cre is a P1 bacteriophage-derived tyrosine recombinase mediating the site-specific recombi...

View Article PDF DOI: 10.14437

Senile Transthyretin Cardiac Amyloidosis in Patients with Plasma Cell Dyscrasias: Importance of Cardiac Biopsy for Making The Correct Diagnosis

Amyloidosis refers to a group of widely diverse conditions characterized by the deposition of insoluble protein within the extracellular space, leading to disruption of normal organ function. AL primary amyloidosis ...

View Article PDF DOI: 10.14437

Topical AC-11 Abates While Applied Actinic Keratoses and Early Squamous Cell Cancers in Hairless Mice Exposed to Ultraviolet A (UVA) Radiation

AC-11 is an aqueous extract of the botanical, Uncaria tomentosa, which has a variety of effects that enhance DNA repair and down regulate inflammation. AC-11 is essentially free of oxindole alkaloids (< 0.05%, w/...

View Article PDF DOI: 10.14437

Healthcare Utilization in Patients with Uncontrolled Epilepsy: A Retrospective Study in a Commercially-Insured U.S. Population

Objective: To evaluate the healthcare and societal economic burden of adjunctively-treated patients with uncontrolled epilepsy. Methods: A retrospective claims database (representative of the commercially insur...

View Article PDF DOI: 10.14437

Effects of Long-Term Fertilization and Soil Native Nutrient on Rice Productivity in Double Rice Cultivation System

Rice (Oryza sativa L.) yield productivity over time under fixed management condition is a severe concern for countries like Bangladesh, where rice is the staple food for the human being. Long term fertilization&nbsp...

View Article PDF DOI: 10.14437

Prevalence of Zidovudine Induced Megaloblastic Anemia among Human Immunodeficiency Virus Positive Patients Attending University of Gondar Hospital Antiretroviral Therapy Clinic, Northwest Ethiopia

Background: The use of antiretroviral treatment containing Zidovudine in HIV infected patients is associated with hematological toxicity to varying degrees of cytopenia particularly megaloblastic anemia. However,&nb...

View Article PDF DOI: 10.14437

Sex Disparity in Cardiovascular Mortality in Patient with End Stage Renal Disease and Type 2 Diabetes Mellitus

Aim: We hypothesized that sex differences relative to the pro-inflammatory and endothelial markers may exist and play a role in the higher CVD mortality of women with End-Stage Renal Disease and Type 2 Diabetes Mell...

View Article PDF

Fear of Hypoglycemia and Patient-Physician Communication in Adult Patients with Type 1 Diabetes Mellitus

Little is known regarding rates of fearing hypoglycemia and predictive factors in Japan. The aim of the study was to investigate the prevalence of a fear of hypoglycemia and predictive factors in patients with ...

View Article PDF

Coronary Artery Calcium Score and Obstructive Sleep Apnoea

Obstructive Sleep Apnoea (OSA) is a sleep related breathing disorder affecting a significant section of middle aged population. The pro inflammatory state that exists in OSA patients contributes to accelerated ...

View Article PDF

Effects of Cissampelos sympodialis Extract in a Murine Model of Streptozotocin-Induced Diabetes

Cissampelos sympodialis (Cs) is an herb used for the treatment of several diseases due to its anti-inflammatory properties. The present study investigated the effect of oral administration of Cs extract on STZ-induc...

View Article PDF

Current Management of Type 1 Autoimmune Pancreatitis: From the Viewpoint of Pancreatic Endocrine and Exocrine Function

Autoimmune Pancreatitis (AIP) is a pancreatic inflammatory disease caused by an autoimmune mechanism. Histologically, two subtypes exist: type 1 characterized by lymphoplasmacytic sclerosing pancreatitis and ty...

View Article PDF

The Diagnostic Dilemma of Intravascular Lymphoma

Introduction Intravascular large B-cell lymphoma is a rare subtype of diffuse large B-cell lymphoma with an estimated frequency of less than one percent of all lymphomas. It has a variety of presentations and i...

View Article PDF DOI: 10.14437

Managing HIV Disease in A Health Department

Objective: To know assistance functions performed in primary and hospital care for patients with HIV disease.  Design: Retrospective  Participants: 167 cases with HIV disease assigned to three health ...

View Article PDF DOI: 10.14437

Role of microRNA-7-1-3p in Prostate Cancer Progression

Prostate cancer (PCa) is one of the most common malignant diseases in western world and now emerging as a challenging disease in developing countries. Although much progress has been done to control of androgen&nbsp...

View Article PDF DOI: 10.14437

Is Reiki an Effective Approach to Pain Management?

Reiki is believed to be an ancient healing practice that originated thousands of years ago. Reiki therapy has no side effects and thought to provide harmony and balance to improve physical, emotional, mental, and sp...

View Article PDF DOI: 10.14437

Nano Suspension Drug Delivery System: An Overview

Nano suspensions have gained great interest in the last decade as a formulation tool for poorly soluble drugs. By decreasing particle sizes nano suspensions enhance dissolution rate and bioavailability of the drug.&...

View Article PDF DOI: 10.14437

A Case of Infantile Miller Fisher Syndrome

We report a 7-month-old female infant with Miller Fisher Syndrome (MFS), presenting with external ophthalmoplegia, blepharoptosis, ataxia, and loss of deep tendon reflexes. We treated the patient with high-dose&nbsp...

View Article PDF DOI: 10.14437

Effect of Laparoscopic Sleeve Gastrectomy on Metabolic Parameters – Data from A Two-Year Prospective Survey

Purpose: Laparoscopic sleeve gastrectomy has proven effectiveness regarding weight reduction, but metabolic consequences, especially in the long-term, have not yet been adequately clarified. The aim of the present s...

View Article PDF DOI: 10.14437

The "Time Factor" and Communication in Oncology and Palliative Care

In the field of medicine, the acquisition of communication skills is essential for an effective, complete and personalized treatment. This is particularly true for delicate fields such as incurable diseases, palliat...

View Article PDF DOI: 10.14437

Comparison of Reported Serving Sizes of Packaged Foods in Costa Rica with National Guidelines

Introduction: Overweight and obesity is growing drastically worldwide, with increasing portion sizes of processed food identified as one of the contributing factors. To date there has been no research looking at the repo...

View Article PDF DOI: 10.14437

Impaired Awareness of Hypoglycemia in Insulin-Treated Patients with Type 2 Diabetes

Impaired Awareness of Hypoglycemia (IAH) is associated with Severe Hypoglycemia (SH). This study investigated the actual state of hypoglycemia, including IAH, in patients with Type 2 Diabetes. A questionnaire s...

View Article PDF

Triptan Is Effective for the Migraine with Aura-Like Headache Associated With Moyamoya Disease

We describe two cases of moyamoya disease associated with headache which had been diagnosed as migraine with aura meeting the International Headache Society criteria. Administration of triptan was clinically ef...

View Article PDF DOI: 10.14437

Shifting Seropositivity for Hepatitis A in Children in Istanbul, Turkey, From 1996 to 2011 and Evaluation of Hepatitis A Associated Risk Factors

Hepatitis A virus (HAV) is transmitted by the fecal-oral route, and the epidemiology of HAV is associated with hygiene and socioeconomic status. In this study, we investigated the seropositivity for HAV and the asso...

View Article PDF DOI: 10.14437

Sustained Release Drug Delivery Systems: A Patent Overview

Sustained Release Drug Delivery System (SRDDS) is designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. Now a day’s fo...

View Article PDF DOI: 10.14437

Sumo-2/3 and Rnf4 Localization to DNA Replication Foci in Cultured Human Cells Over expressing the P150 Subunit of Chromatin Assembly Factor 1

We previously reported that the largest p150 subunit of chromatin assembly factor 1 (p150CAF1), which promotes chromatin assembly in the context of DNA replication, interacts directly and preferentially with small&n...

View Article PDF DOI: 10.14437

Enzymes Involved in Epididymal Function of Corynorhinus Mexicanus Bat

In the Corynorhinus mexicanus four enzymes related to Reactive Oxygen Species (ROS) modulation are present in the cephalic and caudal region of the epididymides during the progress of the epididymis sperms and their...

View Article PDF DOI: 10.14437

An atypical form of favus is undiagnosed for 50 years

Tinea capitis favosa, also termed favus, is a chronic inflammatory dermatophyte infection of the scalp usually caused by Trichophyton schoenleinii. It can be acquired during childhood or adolescence and typically pe...

View Article PDF DOI: 10.14437

Prevention of Chemotherapy-Induced Nausea and Vomiting by Olanzapine in Japanese Female Patients with Early Breast Cancer who had Poor Control with the Standard Antiemetic Regimen

Aim: To evaluate the antiemetic efficacy and safety of olanzapine in Japanese women with nausea and/or vomiting refractory to the standard antiemetic regimen. Methods: We retrospectively reviewed the medical records...

View Article PDF

“Fuzzy”, Homogeneous Configurations

The Ethernet must work. In this paper, we confirm the improvement of e-commerce. WEKAU, our new methodology for forward-error correction, is the solution to all of these challenges. 

View Article PDF DOI: 10.14437

Knowledge, Attitudes and Practices of Oncology Nurses towards Complementary and Alternative Medicine for Cancer Care in Qatar

Aim and objectives: The aim of this study is to investigate the knowledge, attitudes and practices of oncology nurses towards CAM in cancer care in Qatar.  Background: CAM is widely used by patients with cancer...

View Article PDF DOI: 10.14437

An Overview of Antiviral Activity of some Medicinal plants of Africa

Owing to numerous problems of controlling viral diseases many African medicinal plants have been screened for their antiviral activity. A review of studies on this shows that 58 plant species had in-vitro antiviral ...

View Article PDF DOI: 10.14437

A Biochemical Approach towards Inborn Errors of Metabolism

Inborn Errors of Metabolism (IEM) are rare congenital diseases. It arises due to a defect of single genes that code for enzymes that helps to convert substrates into their products by participating in certain metabo...

View Article PDF DOI: 10.14437

Recent Advances, Patent Scenarios and Future Developments on Gastro-Retentive Drug Delivery System: A Patent Overview

Pharmaceutical industries have received much interest in pharmaceutical research in the area of oral drug delivery. Oral administration of drug is the most convenient and versatile way due to the simple and comforta...

View Article PDF DOI: 10.14437

An Alternative of Phosphopeptide Identification using Inclusion List-Driven Targeted Liquid-Tandem Mass Spectrometry for Label-Free Quantitative Tyrosine Phosphoproteomics: Application of Src Inhibitor-Related Signaling Pathway Analyses in Lung Cancer

Tyrosine phosphorylation plays a critical role in cell biological functions, particularly in signal transduction. Mass spectrometry (MS)-based proteomic analysis of tyrosine-phosphorylated (pTyr) proteins ...

View Article PDF DOI: 10.14437

Critical Appraisal of Human Body Composition Techniques

A pubmed hit search teaches us that Human Body Composition (BC) is a frequently used issue in nutrition publications.  Body composition is a branch of human biology and is subject to variable interpretatio...

View Article PDF DOI: 10.14437

Biological Therapeutics and Pharmacovigilance in Italy

Biological Therapeutics (BTs) present a novel frontier for the treatment of autoimmune diseases, such as rheumatoid arthritis, psoriasis, Crohn's disease and several other conditions. BTs constitute highly sele...

View Article PDF

Encapsulation of Insulin Producing Cells for Diabetes Treatment Using Alginate and Cellulose Sulphate as Bioencapsulation Polymers

It has long been the holy grail of cell encapsulation to treat diabetes with insulin producing cells that are shielded from rejection or clearance by the host immune system. Indeed, the idea has been around for more...

View Article PDF

Challenges of Clinical Research in Physical Medicine & Rehabilitation: Considerations from a Working Group from Brazil, USA and Canada

Background: In coming years, the need for clinical research in Physical Medicine and Rehabilitation (PMR) will increase. In face of an aging population and greater emphasis on evidence-based medicine, the field...

View Article PDF DOI: 10.14437

Effects of PNF Method for Hemiplegic Patients with Brachial Predominance after Stroke: Controlled and Blinded Clinical Trial

In stroke, ninety percent of survivors have motor sequelae, being the main one is hemiplegia or hemi paresis, respectively defined as total or partial paralysis of the movements of one side of the body, interfering ...

View Article PDF DOI: 10.14437

Turmeric And Pancreatic Cancer- A Review

Pancreatic cancer belongs to the most malignant gastrointestinal cancers and the treatment options are limited. The two bioactive components of turmeric, curcumin and turmeric oil, are reported to have anticancer pr...

View Article PDF

Vitiligo

View Article PDF DOI: 10.14437

Airborne Particulate Matter and Increased Risk of Lung Cancer- Mechanisms of Carcinogenesis by Reactive Oxygen Species and the Role of Oxidative Stress

Urban air pollution has been one of the most important pollution problem for many decades. Airborne particulate matter (PM) from combustion sources is considered the most important air pollutants for adverse health effects to...

View Article PDF DOI: 10.14437

Complications after Percutaneous Endoscopic Gastrostomy (PEG) in Paediatric Patients

Background and Aim: Percutaneous Endoscopic Gastrostomy (PEG) provides for enteral nutrition in children with feeding problems. PEG, however, is not without complications. The present study has the aim to identify the inciden...

View Article PDF

High Frequency of Vitamin D Deficiency in Patients with Rheumatoid Arthritis

Objectives: Vitamin D (VD) has multiple physiological function including bone-mineral metabolism and musculo-skeletal effects. The purpose of this study is to disclose actual circumstances of VD contentment and char...

View Article PDF

Review of Intra-Abdominal Abscess in Crohn’s Disease

Crohn’s disease is an idiopathic chronic transmural inflammatory condition of the intestine. Common complications include intestinal obstruction,internal and external fistulae, and spontaneous abcess formation...

View Article PDF

Relationship between Numbers of Circulating Endothelial Derived Progenitor Cells and Low Intensity Inflammation in Patients with Metabolic Syndrome and Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM) remains a leading contributor to cardiovascular mortality worldwide. This study was conducted to investigate the pattern of circulating Endothelial Progenitor Cells (EPCs) in T2DM&nbs...

View Article PDF

Isolation and Characterization of Gibberellic Acid 3 Producing Fusarium Sp. from Belgaum Agriculture Land Andits Impact on Green Pea and Rice Growth Promotion

Worldwide ultimate aim of any agriculture sector or farmer is to take maximum yield. Sufficient supply of nutrients and fertilizer are not able to give maximum yield. There are numerous factors which are responsible for low yield,...

View Article PDF DOI: 10.14437

Does Finiflu (Containing Garlic, Onion And Chilli) Provide Symptomatic Relief from Cold and Flu? What is the Evidence Base for this Remedy?

Introduction: It is estimated that adults experience between two and four colds per year and catch roughly double this number. Colds and flus are self-limiting conditions; however, there are a number of treatments to hel...

View Article PDF DOI: 10.14437