Little is known regarding rates of fearing hypoglycemia 
and predictive factors in Japan. The aim of the study 
was to investigate the prevalence of a fear of 
hypoglycemia and predictive factors in patients with 
Type 1 Diabetes Mellitus (T1DM). A questionnaire 
survey on hypoglycemia and patient-physician 
communication was conducted in 197 patients with 
insulin-treated T1DM patients at 16 hospitals and 
clinics. The rate of fearing hypoglycemia was 22.1%. A 
multivariate-adjusted logistic regression analysis found 
that aging (Odds Ratio [OR]: 1.02; 95% Confidence 
Interval [CI]: 1.00-1.04; P=0.049) and Severe 
Hypoglycemia (SH) during the past 1 year (OR: 4.34; 
95% CI: 1.45-13.00; P=0.009) were significant 
determinants of a fear of hypoglycemia. Patients with 
such a fear showed a significantly higher frequency of 
talking with physicians compared to patients without 
such a fear, but there was no difference in carrying a 
diabetic data book or the possession of glucagon. 
Interventions to reduce fears of hypoglycemia are 
needed in the future.