Diabetes Research and Treatment
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Cardiac Remodeling with Excessive Visceral Adiposity beyond Anthropometrics in Asymptomatic Asians
Hui-Chun Lin 1,,3,7, Chun-Ho Yun1,2,4, Kuo-Tze Sung1, 2,3, Chi-In Lo1, 2,3, Jing-Yi Sun4, Ta-Chuan Hung2,3,7, Shun-Chuan Chang1,2,3, Chuan-Chuan Liu5,6,7, Chung-Lieh Hung1,2,3,7*, Charles Jia-Yin Hou2,3,7, Hung-I Yeh2,3,7, Anas Fares10 and Hiram G Bezerra10
Purpose: Visceral Adipose Tissue (VAT) as a source of proinflammatory and biological mediators is implicated in adverse cardiac structure remodeling, functional alternations, and results in Heart Failure (...
Cardiovascular biomarkers and obesity: interact with risk stratification?
Alexander E Berezin*
Obesity remains a leading cause of cardiovascular (CV) events and diabetes worldwide. Although there are at least two main body-size phenotypes (metabolically healthy and metabolically non-healthy) of indi...
The Predictive Value of Circulating Osteopontin in Vascular Calcification and Cardiovascular Risk
Alexander E Berezin*
Vascular Calcification (VC) is the major contributors of Cardiovascular (CV) morbidity and mortality in patients with established Coronary Artery Disease (CAD), diabetes mellitus and Chronic Kidney Disease...
Clinical Factors Associated with Musculoskeletal Injuries in Children and Adolescents with Diabetes Mellitus
Jeffrey A Guy1, Lisa M Knight2, Yinding Wang3, Candler G Mathews III4 and Jeanette M Jerrell5*
Background: To examine the incidence of traumatic and overuse Musculoskeletal Injuries (MSI) in children and adolescents with diagnosed diabetes mellitus, which has been understudied. Methods: Using a popu...
Linear Regression Analysis and Correlation Findings in Hemoglobin Oxidation Studies in Diabetics Blood and Normal Blood: The Effects of Amyl Nitrite and Butyl Nitrite
John Philip Tarburton*
Enhanced susceptibility of amyl nitrite or butyl nitrite induced oxidation of oxyhemoglobin into methemoglobin in the Type 2 diabetics blood compared to normal blood in independent studies was confirmed (P...
“Impaired Phenotype” of Endothelial Cell-Derived Microparticles: Causality Factor Contributed the "Vascular Competence" in Diabetes and Metabolic Syndrome?
Alexander E Berezin*
The recognition of the importance of overweigh / obesity and metabolic syndrome as leading risk factor for diabetes and cardiovascular (CV) complications has greatly increased within last decades. Endothel...
Perspective in the Management of Diabetes Mellitus: Deciphering Beneficial Role of Diet and Nutrients
Kshetrimayum Birla Singh*
Diabetes Mellitus (DM) is a global health problem and increasing all over the world at an alarming rate that appears dramatic as to have been characterized as an epidemic. DM is a chronic metabolic and hor...
Prognostication of Cardiovascular Complications in Metabolic Syndrome Patients: The Role of Vistafin
Alexander E Berezin*
Vistafin is insulin-mimicking adipocytokine secreted from visceral adipose tissue, which plays an essential role in a number of biological processes affected glucose uptake regulation, inflammation, immuni...
Association of KCNJ11 E23K (rs5219) polymorphism to Type 2 diabetes mellitus: a case-control study in Indian population of Eastern Uttar Pradesh
Sunita Singh1*, N K Agrawal2 and Gopeshwar Narayan3
Aim: Potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) gene has a key role in insulin secretion and is of substantial interest as a candidate gene for Type 2 Diabetes (T2D). The curren...
The Association between Three-Dimensional Pericardial Adiposity Measures, Life Quality Scores and Physical Functional Status beyond Anthropometrics in Men
Hui-Chun Lin1, Chuan-Chuan Liu1,2,3,4, Ya-Ching Hsieh6, Chun-Ho Yun7, Fei-Shih Yang7, Charles Jia-Yin Hou1,5, Ta Chuan Hung1,5, Tin-Yu Lin7, Hiram G Bezerra8, Shou-Chuan Shih3,7, Bernard E. Bulwer9,10, Chung-Lieh Hung1,3,5＊, Cheng-Ho Tsai1,7 and Hung-I Yeh1,5
Background: Previous studies demonstrated visceral adiposity in relation to metabolic disorder may mediate systemic inflammation and predict cardiovascular outcomes. However, data regarding visceral adipos...
Perspectives of Canadian Healthcare Professionals on Diabetes Self-Management and Care: Diabetes Attitudes, Wishes and Needs 2 (DAWN2™)
Debbie Hollahan1, Stuart Ross2, Michael Vallis3, Katharina Kovacs Burns4 and Jina Hahn5
Aim: The second Diabetes Attitudes, Wishes and Needs (DAWN2) study aimed to describe the psychosocial challenges faced by People With Diabetes (PWD), their families, and the Healthcare Professionals (HCPs)...
Psychosocial and Management Experiences of Canadian Family Members Living with People with Diabetes: The Second Diabetes Attitudes, Wishes and Needs Study (DAWN2™)
Katharina Kovacs Burns1*, Michael Vallis2, Stuart Ross3, Debbie Hollahan4 and Jina Hahn5
Aim: To explore the psychosocial impacts, needs and wishes of Canadian Family Members (FMs) of People With Diabetes (PWD), as part of the second global Diabetes Attitudes, Wishes and Needs (DAWN2™) s...
Diabetes Mellitus: A Potential Risk for Developing Cancer
Divya Jyothi Reddy, Surya Satyanarayana Singh and Wasia Rizwani*
Epidemiological studies have clearly indicated diabetes as a risk factor for cancer initiation and progression. Both diabetes and cancer are influenced by multiple factors of known and unknown origin. The&...
Relationship between Numbers of Circulating Endothelial Derived Progenitor Cells and Low Intensity Inflammation in Patients with Metabolic Syndrome and Diabetes Mellitus
Alexander E Berezin1*, Alexander A Kremzer2, Tatyana A Berezina3 and Martovitskaya Yu V4
Type 2 Diabetes Mellitus (T2DM) remains a leading contributor to cardiovascular mortality worldwide. This study was conducted to investigate the pattern of circulating Endothelial Progenitor Cells (EPCs) i...
Insulin Resistance Due to Periodontal Disease in an Old Diabetic Female Poodle
Alan Gomes Poppl1*, Fernanda Muller2, Luciana Queiroga3 and Félix Hilário Díaz González4
The purpose of this work was to report a clinical case of a spayed, 13-year-old diabetic poodle on insulin therapy with insulin resistance and poor diabetes control secondary to severe periodontitis. Prior...
Diabetes Mellitus-Types and Prevalence: A Mini Review
Amjid Ahad*
Diabetes Mellitus (DM) is a condition in which a person has a high blood sugar level over a prolonged period. DM arises as a result of complete or relative insufficiency of insulin secretion and/or insulin...
1, 5-Anhydroglucitol as Marker of Short-Term Hyperglycemic Excursions in Well-Controlled Type 2 Diabetes Mellitus: Associations with the Prevalence of Vascular Complications
Felix Kulozik and Christoph Hasslacher
Background: Intermittent states of hyperglycemia have been identified as risk factor for vascular complications of type 2 diabetes mellitus independent from the mean blood glucose level. 1,5-Anhydroglucito...
Representing a Novel Model of Diet-Induced, Inherited Insulin Resistance and Obesity, Atp10c Heterozygous Mice Show Alterations in Glucose Uptake via both Insulin-Dependent and Non-Dependent Pathways
Sarah E Hurst1, Lisa Amelse2, Ling Zhao3 and Madhu S Dhar 2*
Diet-Induced Obesity (DIO) is a major risk factor for a number of disorders including non-insulindependent Type 2 Diabetes Mellitus (T2D). In our novel mouse model, the gene Atp10c is a strong candidate for&nbs...
A Novel Approach for the Management of Diabetes Mellitus
Chandra Kanti Chakraborti*
Recent research has shown that there is a link between metabolic diseases (like diabetes, obesity and cardiovascular diseases) and bacterial population in the gut. The results of such studies indicate that...
Circulating Endothelial-Derived Apoptotic Microparticles as Novel Perspective Biomarker for Diabetes
Alexander E Berezin*
Diabetes mellitus is major independent risk factor for cardiovascular morbidity and mortality worldwide. The endothelium is crucial for preserving endothelial integrity and preventing the development of DM...
Prevalence of Chronic Kidney Disease in Unselected Swedish Patients with Type 2 Diabetes and its Association with Cardiovascular Disease
Carl J Ostgren1* , Anders Broijersen2, Lars Weiss3 and Maria K Svensson4
Aim: To estimate the prevalence of Chronic Kidney Disease (CKD) and albuminuria and its associations to prevalent cardiovascular co-morbidities in patients with type 2 diabetes in a primary care setting in...
Paternal Influence on Glycemic Control at Baseline and One Year Post Diagnosis in Children and Adolescents with Type 1 Diabetes Mellitus
Peter Sand1*, Anna Nilsson Kleiberg2 and Gun Forsander1
Aim: The aim of this exploratory study within an RCT design was to examine the factors with influence on the change in the child’s glycemic control from the onset of Type 1 Diabetes Mellitus (T1DM) t...
Sex Disparity in Cardiovascular Mortality in Patient with End Stage Renal Disease and Type 2 Diabetes Mellitus
Essam Nakhla1, Ruchi Singh2, Sudha Chennasamudram2, Olga Vasylyeva1, Tarek Naguib1 and Tetyana L Vasylyeva2*
Aim: We hypothesized that sex differences relative to the pro-inflammatory and endothelial markers may exist and play a role in the higher CVD mortality of women with End-Stage Renal Disease and Type 2 Dia...
Fear of Hypoglycemia and Patient-Physician Communication in Adult Patients with Type 1 Diabetes Mellitus
Naoki Sakane1*, Kazuhiko Kotani1,2, Kokoro Tsuzaki1, Masami Nishi1, Kaoru Takahashi1,3, Takashi Murata4, Kazunori Yamada4, Kentaro Okazaki5, Katsuyuki Yanagisawa6, Kenichi Yamada7, Nobuichi Kuribayashi8, Yasuo Totsuka9, Toru Hiyoshi10, Motoji Naka11, Masatake Sugimoto12, Yuji Aoki13, Masako Waki14, Miyuki Furuya15, Haruko Kitaoka16, Mariko Oishi17, Ikki Shimizu18, Hiroaki Miyaoka19, Akira Okada20 and Toshikazu Yamamoto21
Little is known regarding rates of fearing hypoglycemia and predictive factors in Japan. The aim of the study was to investigate the prevalence of a fear of hypoglycemia and predictive factors in patients ...
Hemoglobin Oxidation Studies in Diabetics Blood Comparing the Effect of Sodium Nitrite vs. Amyl Nitrite
John Philip Tarburton*
Comparative studies between sodium nitrite and isoamyl nitrite in nitrite induced methemoglobin formation of diabetic’s blood have been undertaken. First the effect of sodium nitrite on human Type 2 ...
Metabolic Syndrome in a Teenager as a Clinical Picture of R482W LMNA Mutation
Anna Wędrychowicz1*, Maciej Borowiec2, Anna Hogendorf3, Wojciech Młynarski3 and Jerzy Starzyk1
Metabolic Syndrome (MS) can be diagnosed from the age of 10 years, when the coexistence of abdominal obesity, glucose metabolism disorders, dyslipidemia, and hypertension is observed. A binding part of MS ...
Vitamin D and the Renal and Cardio Affairs
Ana Paula Silva*, Teresa Jerónimo and Pedro Leão Neves
Impaired Awareness of Hypoglycemia in Insulin-Treated Patients with Type 2 Diabetes
Naoki Sakane1*, Kazuhiko Kotani1,2, Kokoro Tsuzaki1, Masami Nishi1, Kaoru Takahashi1,3, Takashi Murata4, Kazunori Yamada4, Kentaro Okazaki5, Katsuyuki Yanagisawa6, Kenichi Yamada7, Nobuichi Kuribayashi8, Yasuo Totsuka9, Toru Hiyoshi10, Motoji Naka11, Masatake Sugimoto12, Yuji Aoki13, Masako Waki14, Miyuki Furuya15, Haruko Kitaoka16, Mariko Oishi17, Ikki Shimizu18, Hiroaki Miyaoka19, Akira Okada20 and Toshikazu Yamamoto21
Impaired Awareness of Hypoglycemia (IAH) is associated with Severe Hypoglycemia (SH). This study investigated the actual state of hypoglycemia, including IAH, in patients with Type 2 Diabetes. A quest...
How Limited Access Dressing is an Effective Tool for Limb Salvage in Diabetic Patients?
Pramod Kumar
Can Trending Arrows in Continuous Glucose Monitoring Systems Predict Later Glycemia below 0.80g/L?
Concepcion Gonzalez, Elisa Maury, Isabelle Barcos, Henri Gin and Vincent Rigalleau*
Objective: Can Continuous Glucose Monitoring (CGM) systems predict capillary glucose levels < 0.80g/L Research Design and Methods: During their education to the use of CGMS, thirty-three patients&n...
Knowledge on Own Disease and Self-Management in Patients with Type 2 Diabetes in the Swedish Town of Sodertalje
Taloyan Marina*and Wandell Per
Aim: To investigate the ethnic differences in knowledge on own diabetes disease and selfmanagement in Assyrian/Syrian-born and Swedishborn patients in Swedish town. Methods: This cross-sectional, questionnaireb...
Hypoglycemia - Low Blood Glucose - Underestimated and Unexplored Problems in People with Type 2 Diabetes
Janeth Leksell 1, 2, 5*, Andersson M 2, 3 and Carlsson BM 2, 4.
The aim: was to ascertain the frequency of selfreported hypoglycemia among people with type 2 diabetes; a further aim was to determine how participants received information about hypog...
Encapsulation of Insulin Producing Cells for Diabetes Treatment Using Alginate and Cellulose Sulphate as Bioencapsulation Polymers
Brian Salmons1, Eva Maria Brandtner1,2, John A Dangerfield1 and Walter H Gunzburg1,3
It has long been the holy grail of cell encapsulation to treat diabetes with insulin producing cells that are shielded from rejection or clearance by the host immune system. Indeed, the idea has been aroun...
The Role of Sex and Age in the Development of Type 2 Diabetes in Obese Subjects
Neri A1, Banci M2, Saccucci P1, Coppeta L1, Magrini A1 and Gloria-Bottini F1*