Vascular Calcification (VC) is the major contributors of 
Cardiovascular (CV) morbidity and mortality in patients with 
established Coronary Artery Disease (CAD), diabetes mellitus 
and Chronic Kidney Disease (CKD). Amongst several factors in 
abundant involved in the molecular mechanisms of regulation of 
ectopic calcification, Osteopontin (OPN) appears to be promised, 
while its role in the VC is controversial. OPN is chemokine-like 
matricellular phosphor glycol proteins with abilities to regulate 
inflammation, bone formation, hematopoiesis, and angiogenesis. 
It is known that the elevated circulating level of OPN may 
independently predict VC in subjects with established CAD, 
diabetes mellitus and CKD. The peak concentration of OPN in 
peripheral blood used to assay aimed to assume the risk of the 
CV-related clinical outcomes. The editorial recaps our knowledge 
regarding OPN as a biological marker of VC with possible 
predictive value.