Open Access Peer Reviewed ISSN: 2378-6221

Gastro

International open-access publishing for high-quality research, reviews, case studies, and scholarly communication.

Submit Manuscript
Original Research Article in Press

Vitamin A Supplementation of Malaria-infected Pregnant Women and Infant Birth Weight Outcomes A Case Study of Ebonyi State, Nigeria

Elom MO1, Okafor FC 2* and Eyo JE2
Corresponding Author: Okafor FC
Received: Jul 09, 2014
Accepted: Jul 31, 2014
Published: Aug 02, 2014
Views: 3
DOI: N/A

Abstract

A total of 152 malaria parasitaemic pregnant 
women of varying ages and gravidities, whose pregnancies 
had advanced up to the 6th months and above, were 
enrolled in the study. Seventy-six (76) each were 
randomised into supplemented and placebo groups. Venous 
blood was collected from each woman and examined for 
malaria parasitaemia, using standard parasitological 
techniques. Ten thousand international units of vitamin A 
was administered to the supplemented group once daily for 
three times per week. The placebo group also received 
vitamin A soft gels devoid of its active ingredients three 
times weekly. The regimen was continued as the women 
were followed up until delivery of their babies. Birth 
weights of the infants were determined with the use of 
weighing scales, within 72 hours post-delivery. Cross 
tabulations were used to calculate the percentages of low 
birth weights. The mean birth weights of the infants were 
analysed, using analysis of variance (ANOVA) and Fisher’s 
least significance difference (FLSD), for mean separation. 
T-test was used to compare birth weight in supplemented 
group with those in the placebo group. Statistical 
significance was established at p< 0.05.  The multigravids dominated in the study. The primigravids 
had the least mean age while the multigravids had the 
highest. When the overall supplemented and placebo 
groups were compared the placebo groups had higher 
number of low birth weights that were statistically 
significant (p< 0.05) among the infants of the 8th month 
group women. The mean birth weights were generally 
statistically higher in the supplemented group than in the 
placebo group, except in a few cases with no significant 
differences. Vitamin A has proved to be efficacious in 
improving infant birth weights. Therefore, its 
supplementation to pregnant women at safe periods and 
dosages is advocated. 
Keywords: Vitamin A, Supplementation, Malaria, 
Pregnancy, Birthweight 

Download PDF
Okafor FC (2013), Vitamin A Supplementation of Malaria-infected Pregnant Women and Infant Birth Weight Outcomes A Case Study of Ebonyi State, Nigeria. Gastro 2: 109.
Copyright: Copyright: © 2014 Goa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Version 3.0, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Indexed In
Google Scholar
DOAJ
PubMed
Scopus