Rapid resistance to mupirocin occurs among
strains of Methicillin-Resistant Staphylococcus Aureus
(MRSA) which the main etiological agent is causing
community-acquired and hospital-acquired infections.
Powdered samples of Sr-doped glass, of composition 70
SiO2- (30–x) CaO- xSrO were prepared by sol – gel
method. XRD and FTIR confirmed the calcined glass
existed in the amorphous state. Sr doped glass exhibited
antibacterial effect onmupirocin resistant MRSA strains
by the agar-disk diffusion method. The inhibition zone
increased as the concentration of Sr ions was increased. Sr
release was dependent on bioactive glass composition
with increasing Sr substitution resulting in higher
concentrations in the medium. Sr for Ca substitution in the
glass is a promising bactericidal bioactive material till 3%
SrO, but SrO substitution above that ratio doesn’t further
improve bactericidal effect.
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Synthesis of Bioactive Glass and its Antibacterial Effect on Mupirocin Resistant, Methicillin-Resistant Staphylococcus Aureus
Samaa A Taha1, Mahmoud M Elhaig2* and Azza Nady MH3
Corresponding Author: Mahmoud M Elhaig
Received: Apr 21, 2015
Accepted: May 05, 2015
Published: May 08, 2015
Views: 4
DOI: 10.14437
Abstract
Mahmoud M Elhaig (2015 Synthesis of Bioactive Glass and its Antibacterial Effect on Mupirocin Resistant, Methicillin
Resistant Staphylococcus Aureus. Aperito J Infect Dis Vaccines 1:108
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Copyright: © 2015 AJIDV. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Version 3.0, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and source are credited
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