Controlled drug delivery system is to make sure safety and to improve effectiveness of the drugs as well as patient compliance. A controlled release system includes any delivery system that achieves slow release of the drug over an extended period of time. This is achieved by better control of plasma drug level and less frequent dosing. Successful commercialization of a controlled release formulation is frequently challenging and involves consideration of many factors such as physiochemical properties of the drug, physiological factors, and manufacturing variables. The rationalization for the development of controlled release drug delivery system of a drug is to improve its therapeutic benefits, minimizing its side effects even as improving the management of the diseased condition. It is the purpose of this piece of writing to comprehensively review drug delivery system design for control release by discussing the recent patents available.