Aperito Journal of Drug Designing and Pharmacology
International open-access publishing for high-quality research, reviews, case studies, and scholarly communication.
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The Effect of Eplerenone on Circulating Microparticle Numbers in Patients with Chronic Heart Failure
Alexander E Berezin*1, Alexander A Kremzer2, Tatyana A Samura2, Tatyana A Berezina3, Peter Kruzliak4
The study aim was to evaluate whether the Mineralocorticoid Receptors (MR) antagonist eplerenone, effects circulating microparticles originated from apoptotic and activated endothelial cells (EMP) in Chron...
Computationally Designed Prodrugs Based On Enzyme Models
Rafik Karaman*1,2
The striking efficiency of enzyme catalysis has inspired many organic chemists to explore enzyme mechanism(s) by studying certain intramolecular processes (enzyme models) which proceed faster than their&nb...
Antibiotic Development in an Era of Burgeoning Bacterial Resistance- Therapies for Complicated Skin Infections
Glenn S Tillotson*
A Randomized Trial of Ayurvedic Herbal Remedies for Sleep Quality: An App-Based Assessment
Roshini S Asirvatham, Susan E Bisco1 and Samuel J Asirvatham1,2*
Introduction: The quest for treatment of insomnia without side effects has been elusive and thus has led to herbal therapies. Two such supplements are Ayurvedic-based herbs, Ashwagandha and valerian. Even ...
Stem Cells and Its Application in Pharmacology
K Ramya, P Selvaraj, N Rani and P Sankar*1
Pharmaceutical Controlled Release Drug Delivery Systems: A Patent Overview
Sahilhusen I Jethara1, 2*, Mukesh R Patel 2
Controlled drug delivery system is to make sure safety and to improve effectiveness of the drugs as well as patient compliance. A controlled release system includes any delivery system that achieves slow r...
Nano Suspension Drug Delivery System: An Overview
Sahilhusen I Jethara1, 2*, Mukesh R Patel2 and Alpesh D Patel
Nano suspensions have gained great interest in the last decade as a formulation tool for poorly soluble drugs. By decreasing particle sizes nano suspensions enhance dissolution rate and bioavailability of ...
Cardiovascular Safety of Incretin-Based Drugs in Type Two Diabetes Mellitus Patients
Alexander E Berezin*
Diabetes Mellitus (DM) is a chronic metabolic disease with complicated complex pathogenesis. Frequency of newly DM arises worldwide and associated with steadily increased morbidity and mortality due to DM-...
Sustained Release Drug Delivery Systems: A Patent Overview
Sahilhusen I Jethara1, 2*, Mukesh R Patel1, 2 and Alpesh D Patel2
Sustained Release Drug Delivery System (SRDDS) is designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. Now a day&...
Recent Advances, Patent Scenarios and Future Developments on Gastro-Retentive Drug Delivery System: A Patent Overview
Sahilhusen I Jethara1, 2*, Mukesh R Patel 2 and Saad M Patiwala2
Pharmaceutical industries have received much interest in pharmaceutical research in the area of oral drug delivery. Oral administration of drug is the most convenient and versatile way due to the simple an...
Recent Approaches and Patent Survey on Colon Targeted Drug Delivery System
Sahilhusen I Jethara1, 2* and Mukesh R Patel1, 2
Targeting drugs to the colon is one of the modern research areas in pharmaceutical sciences at the deciding time, place and exact amount, and improving patient flexibility, compliance and bioavailability. ...