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Original Research Vol. 1, Issue 1 (2014)

Prevalence of Zidovudine Induced Megaloblastic Anemia among Human Immunodeficiency Virus Positive Patients Attending University of Gondar Hospital Antiretroviral Therapy Clinic, Northwest Ethiopia

Agerie Tadele1, Abdela Kedir2, Bamlaku Enawgaw1*, Mulugeta Melku1 and Betelihem Terefe1
Received: Oct 15, 2014
Accepted: Nov 20, 2014
Published: Nov 23, 2014
Views: 11
DOI: 10.14437

Abstract

Background: The use of antiretroviral treatment containing Zidovudine in HIV infected patients is associated with hematological toxicity to varying degrees of cytopenia particularly megaloblastic anemia. However, there is scarcity of data which assesses prevalence of AZT induced megaloblastic anemia among HIV patients taking ART in Ethiopia. 

Objective: The aim of this study was to assess the prevalence of Zidovudine induced megaloblastic anemia in HIV/AIDS patients taking ART at University of Gondar Hospital, Northwest Ethiopia. 

Method: A retrospective study was conducted among HIV/AIDS patients who were attending Gondar University Hospital between January 2012 and February 2013. Data was collected from 319 patients’ chart and statistical analysis was done on SPSS version 20. 

Result: Prevalence of AZT induced anemia was 11.3% at the 6 month of AZT based treatment. Most of them (n = 29, 80.6%), developed macrocytic anemia. Age shows 
significant association with the incidence of anemia (P = 0.042) while sex, baseline CD4 cell count, presence of opportunistic infection, HIV clinical stage and baseline hemoglobin were not associated. 

Conclusion: This study showed high prevalence of macrocytic anemia after 6th months of treatment with AZT based ART. 

 

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Citation: Bamlaku Enawgaw (2014), Prevalence of Zidovudine Induced Megaloblastic Anemia among Human Immunodeficiency Virus Positive Patients Attending University of Gondar Hospital Antiretroviral Therapy Clinic, Northwest Ethiopia. HIV Adv Res Dev Open Access 1:105
Copyright: Copyright: © 2014 HARDOA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Version 3.0, which permits
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