Building bases of scientific evidence about nitrite
in humans continues to oppose the general safety in human
health. Therefore, we investigate the testicular tissue
inflammation caused by oral administration of sodium
nitrite. Twenty adult male SD rats were used. Ten rats
received oral 80mg/kg sodium nitrite daily for twelve
weeks; the other rats were left as negative control. Testis
were weighed and the testicular tissue homogenates were
used for measurements of Malondialdehyde (MDA),
reduced glutathione, Tumor Necrosis Factor (TNF)-α and
Interleukin (IL)-1β. Sodium nitrite resulted in significant
increase in testis weight and Gonado-Somatic index as well
as testicular tissue level of MDA, TNF-α and IL-1β.
Moreover, oral sodium nitrite resulted in significant
reduction in testicular tissue concentration of reduced
glutathione. In conclusion, chronic oral sodium nitrite
induced changes in the weight of rat testis accompanied by
elevation in the testicular tissue level of oxidative stress
markers and inflammatory cytokines.
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Oralsodium Nitrite Enhanced Oxidative Stress and Inflammatory Cytokines Levels in Testicular Tissue
Mohammed M H Al-Gayyar1, 2*, Abdullah Alyoussef3
Corresponding Author: Mohammed M H Al-Gayyar
Received: Apr 20, 2014
Accepted: May 08, 2014
Published: May 11, 2014
Views: 3
DOI: 10.14437
Abstract
Mohammed M H Al-Gayyar (2015), Oralsodium Nitrite Enhanced Oxidative Stress and Inflammatory Cytokines Levels
in Testicular Tissue. Clin Res Dev Open Access 1:111
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Copyright: © 2015 CRDOA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Version 3.0, which permits
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