Clinical Research and Development

Neuroprotective Effect of L-Norvaline against Ischemic Brain Damage in Rats

Waleed Barakat1,2,*, Ahmad Fahmy1 and Mohamed Askar1

Stroke is the second leading cause of death and permanent disability in adults worldwide. The treatment options for ischemic are very limited and new therapies are still required.       &nbs...

Ameliorative Effect of Glycyrrhizic Acid against Doxorubicin-Induced Cardiotoxicity in Rats

Waleed Barakat1,2*, Sherif El-kannishy1,3, Shimaa M Elshazly2, Amr A A Mahmoud2 and Naglaa A Ahmed4

Doxorubicin (DOX) is a potent anticancer drug whose application is hampered by its cardiotoxicity mediated by oxidative stress and inflammation.  Glycyrrhizic acid (glycyrrhizin) is a natural compound&nbsp...

Evaluation Of Leukocytes Tumor Necrosis Factor Receptor 2 In Acute Leukemia Patients

Mohammed Al-Gayyar

Oralsodium Nitrite Enhanced Oxidative Stress and Inflammatory Cytokines Levels in Testicular Tissue

Mohammed M H Al-Gayyar1, 2*, Abdullah Alyoussef3

Building bases of scientific evidence about nitrite in humans continues to oppose the general safety in human health. Therefore, we investigate the testicular tissue inflammation caused by oral administrat...

The Association between Serum under carboxylated Osteocalcin Level and Type-2 Diabetes Mellitus: Results from the Kyushu and Okinawa Population Study

Norihiro Furusyo*1,2, Hiroaki Ikezaki2, Takeo Hayashi2, Takeshi Ihara2, Satoshi Hiramine2, Fujiko Mitsumoto2, Kazuya Ura2, Koji Takayama2, Kazuhiro Toyoda1, Eiichi Ogawa1,2, Mosaburo Kainuma1, Masayuki Murata1 and Jun Hayashi3

Objectives: Diabetes can affect bone via obesity, hyperglycemia, hyperinsulinemia, and hypoinsulinemia. Osteocalcin (OC) is a non-collagenous protein of the bone that contributes to bone formation. A popul...

Establishing and Validation of Modified CRE/Loxp System Useful In Temporal and Spatial Control of Genetic Knocking Out Using In Vitro Approaches by Induced Alpha Complementation

Ahmed M Hamdan1, 2*, Mohammed M H Al-Gayyar3, 4 and Abdullah A Alyoussef5

DNA recombinases are used to manipulate the genomic structure and to control the genetic expression in all living organisms. Cre is a P1 bacteriophage-derived tyrosine recombinase mediating the site-specif...

Anaesthesia for Caesarean Section in an Achondroplastic Dwarf

Rahul Garg* and Pamela Angle

Achondroplasia is an inherited skeletal disorder affecting bone growth and development.  It presents the most common cause of dwarfism in humans. Associated anatomical and physiological changes presen...

Anaesthesia for Caesarean Section in an Achondroplastic Dwarf

Rahul Garg* and Pamela Angle

Achondroplasia is an inherited skeletal disorder affecting bone growth and development.  It presents the most common cause of dwarfism in humans. Associated anatomical and physiological changes presen...

The Diagnostic Dilemma of Intravascular Lymphoma

Lizette F Lopez1, Mahmoud Aly2, Yan H Cheng*1, 3, and Aileen Novero1

Introduction Intravascular large B-cell lymphoma is a rare subtype of diffuse large B-cell lymphoma with an estimated frequency of less than one percent of all lymphomas. It has a variety of presentat...

Birth of an Online and Open Access Journal: Journal of Clinical Research and Development

Gerald Mboowa1*

Shifting Seropositivity for Hepatitis A in Children in Istanbul, Turkey, From 1996 to 2011 and Evaluation of Hepatitis A Associated Risk Factors

Abdulkadir Bozaykut, Rabia Gonul Sezer*, Vildan Akcan, Cem Paketci and Lale Pulat Seren

Hepatitis A virus (HAV) is transmitted by the fecal-oral route, and the epidemiology of HAV is associated with hygiene and socioeconomic status. In this study, we investigated the seropositivity for HAV an...

Why Pathologists Have Not Discovered ARVD?

Guy Fontaine

Critical Appraisal of Human Body Composition Techniques

Jan Pieter Clarys1, Jonathan Tresignie1, Erik Cattrysse1 and Aldo Scafoglieri1,2*

A pubmed hit search teaches us that Human Body Composition (BC) is a frequently used issue in nutrition publications.  Body composition is a branch of human biology and is subject to variable int...

Epidemiological Analysis of Congenital Cataract in a Sample of Iraqi Patients

Suzan AMA Kareem, Ali A Mahmood* and Nadia A Abdul-Lateef

Aim and epidemiological Cross sectional study to determine the most common causes of congenital cataract in a sample of Iraqi patients referred to the main tertiary eye center in Iraq. Setting: Ibn Al...

Challenges of Clinical Research in Physical Medicine & Rehabilitation: Considerations from a Working Group from Brazil, USA and Canada

Lauren Richardson1, Marta Imamura3, Magdalena Sarah Volz1,12, Moises Lima3, Marcos Renato de Assis3, Paolo Bonato1, Christina May Moran de Brito8, Hsin Fen Chien11, Andrea Dompieri Furlan5, Alexandra Passos Gaspar8,10, Wu Tu Hsing3, Hermano Igo Krebs6, Henry Lew2, Eduardo Carvalho Rocha Mello9, André Silva Pedroso3, Marcelo Riberto4, Isabel Salles Chateaubriand8, Maria Matilde de Mello Sposito7, Linamara Rizzo Battistella3, Ross Zafonte1 and Felipe Fregni1*.

Background: In coming years, the need for clinical research in Physical Medicine and Rehabilitation (PMR) will increase. In face of an aging population and greater emphasis on evidence-based medicine,&nbsp...