Aim: To estimate the prevalence of Chronic Kidney
Disease (CKD) and albuminuria and its associations to
prevalent cardiovascular co-morbidities in patients with
type 2 diabetes in a primary care setting in Sweden.
Patients and Methods: Cross-sectional data on
demography,
laboratory
measurements,
current
medication, previous cardiovascular disease and major
events of hypoglycaemia during the last 12 months was
consecutively recorded from 53 primary care centers.
Stage of CKD was defined based on the presence of
albuminuria and estimated Glomerular Filtration Rate
(eGFR) according to KDIGO. Albuminuria was measured
using the urinary albumin-creatinine ratio.
Results: We included 362 men and 226 women aged
68.5±9.3 years with a mean diabetes duration 9.9±7.2
years. 220 patients (37%) were categorized as having
CKD stage 1-5, 105 subjects (18%) CKD 1-2, and 115
subjects (20%) CKD 3-5. In the CKD 1-5 categories,
micro albuminuria was prevalent in 128 (58.2%) subjects
and macro albuminuria in 27 (12.3%) subjects. The Odds
Ratio (OR), adjusted for age and gender, for subjects with
CKD 3-5 for having retinopathy was 2.71 (95% CI 1.14
to 6.25, p=0.02) and for myocardial infarction 1.91 (95%
CI 1.04 to 3.45, p=0.03) compared with CKD 0-2. Levels of hemoglobin were lower (133 ±14 g/L vs. 143 ±12 g/L)
in CKD 3-5 compared to CKD 0-2 (p<0.01).
Furthermore, the prevalence of vascular disease (p=0.03)
and ischemic stroke (p=0.02) were higher in subjects with
albuminuria compared with individuals without.
Conclusion: Chronic kidney disease is common in type 2
diabetes in a primary care setting and associated with
prevalent vascular co-morbidities
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ISSN: 2377-7206
Diabetes Research and Treatment
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Prevalence of Chronic Kidney Disease in Unselected Swedish Patients with Type 2 Diabetes and its Association with Cardiovascular Disease
Carl J Ostgren1* , Anders Broijersen2, Lars Weiss3 and Maria K Svensson4
Corresponding Author: Carl J Ostgren
Received: Oct 21, 2014
Accepted: Dec 12, 2014
Published: Dec 15, 2014
Views: 4
DOI: N/A
Abstract
Carl J Ostgren (2014), Prevalence of Chronic Kidney Disease in Unselected Swedish Patients with Type 2 Diabetes and
its Association with Cardiovascular Disease. Diabetes Res Treat Open Access 1:116
Copyright:
Copyright: © 2014 DRTOA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Version 3.0, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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