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Prevalence of Chronic Kidney Disease in Unselected Swedish Patients with Type 2 Diabetes and its Association with Cardiovascular Disease

Carl J Ostgren1* , Anders Broijersen2, Lars Weiss3 and Maria K Svensson4
Corresponding Author: Carl J Ostgren
Received: Oct 21, 2014
Accepted: Dec 12, 2014
Published: Dec 15, 2014
Views: 4
DOI: N/A

Abstract

Aim: To estimate the prevalence of Chronic Kidney 
Disease (CKD) and albuminuria and its associations to 
prevalent cardiovascular co-morbidities in patients with 
type 2 diabetes in a primary care setting in Sweden.  
Patients and Methods: Cross-sectional data on 
demography,
 laboratory
 measurements, 
current 
medication, previous cardiovascular disease and major 
events of hypoglycaemia during the last 12 months was 
consecutively recorded from 53 primary care centers. 
Stage of CKD was defined based on the presence of 
albuminuria and estimated Glomerular Filtration Rate 
(eGFR) according to KDIGO. Albuminuria was measured 
using the urinary albumin-creatinine ratio. 
Results: We included 362 men and 226 women aged 
68.5±9.3 years with a mean diabetes duration 9.9±7.2 
years. 220 patients (37%) were categorized as having 
CKD stage 1-5, 105 subjects (18%) CKD 1-2, and 115 
subjects (20%) CKD 3-5. In the CKD 1-5 categories, 
micro albuminuria was prevalent in 128 (58.2%) subjects 
and macro albuminuria in 27 (12.3%) subjects. The Odds 
Ratio (OR), adjusted for age and gender, for subjects with 
CKD 3-5 for having retinopathy was 2.71 (95% CI 1.14 
to 6.25, p=0.02) and for myocardial infarction 1.91 (95% 
CI 1.04 to 3.45, p=0.03) compared with CKD 0-2. Levels  of hemoglobin were lower (133 ±14 g/L vs. 143 ±12 g/L) 
in CKD 3-5 compared to CKD 0-2 (p<0.01). 
Furthermore, the prevalence of vascular disease (p=0.03) 
and ischemic stroke (p=0.02) were higher in subjects with 
albuminuria compared with individuals without. 
Conclusion: Chronic kidney disease is common in type 2 
diabetes in a primary care setting and associated with 
prevalent vascular co-morbidities

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Carl J Ostgren (2014), Prevalence of Chronic Kidney Disease in Unselected Swedish Patients with Type 2 Diabetes and its Association with Cardiovascular Disease. Diabetes Res Treat Open Access 1:116
Copyright: Copyright: © 2014 DRTOA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Version 3.0, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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