In this review, randomized controlled trials of behavioral interventions for reducing the risk of HIV in occupational settings, were systematically identified through electronic and hand searches, they were then classified and then assessed for methodological quality. Data were analyzed using meta-analysis. This study found that condom use was the most effective intervention for reducing the risk of HIV infection among workers in occupational settings. The provision of Information, Education and Communications (IEC) material, reducing the number of sex partners, improving care for Sexually Transmitted Infections (STIs) and HIV, and increasing knowledge, Attitudes, Practices and Behaviors (KAPBs) were also effective in reducing the risk of HIV among workers. Recommendations coming from this study have immediate implications for service delivery in occupational settings. Knowing which behaviour change intervention is most effective will assist employers in occupational settings in allocating resources appropriately.