Endothelial Progenitor Cells (EPCs) are recognized a 
circulating pool of primitive endothelial precursors of different 
origin from bone marrow or peripheral tissues, which express on 
their surface endothelial markers, i.e. CD45-, CD34+, CD144+, 
CD309 etc. There are at least two types of EPCs: early outgrowth 
EPCs and late outgrowth EPCs, which distinguish each other their 
structure, function, expression of CD markers and gene 
expression. Whether various immune phenotypes of circulating 
EPCs may play similar role in endothelial homeostasis acting as 
endogenous repair system is not fully understand. However, both 
immune phenotype EPCs are involved in the pathogenesis of CV 
diseases across all stages of CV continuum. The short 
commentary is depicted the possibility to use a dysfunction of 
different EPCs as a predictive biomarker of CV disease 
development with promising discriminative value to relate to CV 
clinical outcomes.