T. whipplei, the causative agent of classic 
Whipple´s disease, also produces acute, sub-acute and 
chronic localized forms of infection such as endocarditis. 
Blood culture of patients with T. whipplei endocarditis 
used to be negative and most of the cases are confirmed 
when molecular analyses of the heart valves, surgically 
obtained, are performed. The development of molecular 
tools has allowed increasing the number of cases of 
endocarditis due to this microorganism. This review 
describes the epidemiological and clinical characteristics, 
diagnosis, and treatments used in the 84 cases of T. 
whipplei endocarditis, to our knowledge, reported on the 
medical literature.