Diabetes mellitus is major independent risk factor for 
cardiovascular morbidity and mortality worldwide. The 
endothelium is crucial for preserving endothelial integrity 
and preventing the development of DM-related vascular 
injury and is considered an important targeting for 
traditional risk factors. The Endothelial-derived apoptotic 
MicroParticles (EMPs) are novel biological marker of 
endothelium injury and vasomotion disorders that are 
involved in pathogenesis of DM, cardiovascular, and 
inflammatory diseases. The controversial opinions 
regarding impact of circulating EMPs in major 
cardiovascular and metabolic diseases and summary of 
the perspective regarding implementation of the EMPsas 
component of the risk stratification model are discussed.