Diabetes mellitus is major independent risk factor for cardiovascular morbidity and mortality worldwide. The endothelium is crucial for preserving endothelial integrity and preventing the development of DM-related vascular injury and is considered an important targeting for traditional risk factors. The Endothelial-derived apoptotic MicroParticles (EMPs) are novel biological marker of endothelium injury and vasomotion disorders that are involved in pathogenesis of DM, cardiovascular, and inflammatory diseases. The controversial opinions regarding impact of circulating EMPs in major cardiovascular and metabolic diseases and summary of the perspective regarding implementation of the EMPsas component of the risk stratification model are discussed.