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Autoimmune Diseases and Therapeutic Approaches

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Original Research Vol. 1, Issue 2 (2014)

Current Management of Type 1 Autoimmune Pancreatitis: From the Viewpoint of Pancreatic Endocrine and Exocrine Function

Lingaku Lee1, Tetsuhide Ito1*, Masayuki Hijioka1, Hisato Igarashi1, Keijiro Ueda1, Takashi Fujiyama1, Yuichi Tachibana1, Ken Kawabe1, Robert T Jensen2, Kazuhiko Nakamura1, Masaki Kato1, Koichi Suzuki3 and Ryoichi Takayanagi1
Corresponding Author: Tetsuhide Ito
Received: Sep 25, 2014
Accepted: Nov 12, 2014
Published: Nov 16, 2014
Views: 9
DOI: N/A

Abstract

Autoimmune Pancreatitis (AIP) is a pancreatic inflammatory disease caused by an autoimmune mechanism. Histologically, two subtypes exist: type 1 characterized by lymphoplasmacytic sclerosing pancreatitis and type 2 characterized by idiopathic duct-centric chronic pancreatitis. Type 1 AIP often involves extra pancreatic lesion, and also known as a pancreatic lesion of systemic “immunoglobulin G4 (IgG4)-related disease”. In addition, pancreatic endocrine dysfunction induced diabetes mellitus and exocrine dysfunction is common complications. While steroid therapy improves the outcome of the disease in some patients including pancreatic endocrine/exocrine function, others do not respond to steroids that results in the eventual progression to pancreatic ndocrine/exocrine dysfunction, such as chronic pancreatitis. In the management of type 1 AIP, presence of pancreatic endocrine/exocrine function should always be considered, in addition to the regular steroid therapy. 

Keywords:Autoimmune, pancreatitis; Diabetes mellitus; Endocrine dysfunction; Exocrine Immunoglobulin G4 (IgG4); Steroid therapy  dysfunction; 

Abbreviations: AIP: Autoimmune Pancreatitis; AQP-1: aquaporine-1; CP: Chronic Pancreatitis; CFTR: Cystic Fibrosis Transmembrane Conductance Regulator; DM: 
Diabetes Mellitus; GEL: Granulocyte Epithelial Lesions; IDCP: Idiopathic Duct-centric Chronic Pancreatitis; IgG4: Immunoglobulin G4; Sclerosing Pancreatitis  LPSP: LymphoPlasmacytic 

 

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Tetsuhide Ito (2014), Current Management of Type 1 Autoimmune Pancreatitis: From the Viewpoint of Pancreatic Endocrine and Exocrine Function. Autoimmune Dis Ther Approaches Open Access 1:105
Copyright: Copyright: © 2014 ADTAOA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Version 3.0, which permits
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