Autoimmune Diseases and Therapeutic Approaches
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2017 ACR/EMA Revised Criteria for too Early Diagnosis of Granulomatosis with Polyangiitis (GPA)
Iraj Salehi-Abari
Granulomatosis with polyangiitis (GPA) or Wegener’s granulomatosis is a systemic necrotizing vasculitis with small sized vessel involvement and granulomatous inflammation of ENT and/or Lung and/or Ki...
2016 New York Revised Criteria for too Early Diagnosis of Ankylosing Spondylitis (AS)
Iraj Salehi-Abari
Ankylosing Spondylitis (AS) is a chronic inflammatory systemic disease belonging to the SpondyloArthritidies with axial joint involvement and enthesitis, with or without peripheral arthritis and systemic i...
Practical Guideline for General Practitioners (GP) to approach to the Patients Suspected to have Primary Sjogren’s Syndrome
Iraj Salehi-Abari
Sjogren’ Syndrome (SS) is a chronic autoimmune disease presenting with clinical hallmark of dry eyes, dry mouth and salivary gland swelling and histological hallmark of lymphocytic infiltration of ex...
Subclinical Behcet’s Disease
Iraj Salehi-Abari
Behcet’s Disease (BD) is a chronic inflammatory multisystem disease belongs to the Vasculitidies with small, medium and large sized vessel involvement. This disorder is characterized by Oral aphthosi...
Practical Guideline for General Practitioners (GP) to Approach to the Patients Suspected to have Behcet’s Disease
Iraj Salehi-Abari
“2016 Novel Guideline” Approaching Towards Joint Pain
Iraj Salehi-Abari
In the history of the patient with joint pain we have to know whether or not the joint pain is mechanical or inflammatory, acute or chronic and traumatic or non-traumatic. In the physical examination of th...
Pre-Ankylosing Spondylitis State
Iraj Salehi-Abari
Ankylosing Spondylitis (AS) is a chronic inflammatory systemic disorder belonging to the SpondyloArthridies with axial joint involvement and enthesitis, with or without peripheral arthritis and systemic in...
2016 ACR/EULAR Revised Criteria for too Early Diagnosis of Rheumatoid Arthritis
Iraj Salehi-Abari
Rheumatoid Arthritis (RA) as a chronic progressive systemic autoimmune disease with hallmark of chronic erosive polyarthritis is the most common inflammatory articular disorder. Its overall prevalence is 1...
2016 ACR Revised Criteria for Early Diagnosis of Giant Cell (Temporal) Arteritis
Iraj Salehi-Abari
Giant Cell Arteritis (GCA) is a systemic vasculitis involving medium to large sized vessels most commonly the cranial branches of the arteries originating from the aortic arch. It is called temporal arteri...
2016 ACR Revised Criteria for Early Diagnosis of Knee Osteoarthritis
Iraj Salehi-Abari
Osteoarthritis (OA) is cartilage failure resulting in joint pain and loss of joint functions. Knee OA is the OA of knee that mechanical forces have major effect on initiation and progression of it. Knee OA...
2016 Novel Criteria for Early Classification of SpondyloArthritidies
Iraj Salehi-Abari
The SpondyloArthritidies (SpA) are a group of chronic inflammatory diseases characterized by sacroiliitis, spondylitis, enthesitis, arthritis and dactylitis. They have a strong genetic back ground especial...
Schistosomiasis: An Association with Autoimmunity
Nagwa Mostafa El-Sayed1 and Manar Ezzelarab Ramadan2
The association between Schistosomes infection and autoimmunity has been studied extensively in the medical literature. Schistosomiasis might induce autoimmune activity by several mechanisms: molecular mim...
Recent Updates in Transfusion Transmitted Parasitic Diseases
Nagwa Mostafa El-Sayed
A number of parasitic diseases have been reported to be transmitted by blood transfusion, including malaria, leishmaniasis, Chagas' disease, babesiosis, toxoplasmosis and filariasis. Majority of blood bank...
2015 ACR/SLICC Revised Criteria for Diagnosis of Systemic Lupus Erythematosus
Iraj Salehi-Abari*
Pregnancy in Patients with SLE
Sayumi Baba1, 2*, Hiroshi Okamoto2 and Hisashi Yamanaka1
Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease predominantly affecting women of childbearing age. Pregnancy in women with SLE is associated with higher fetal and maternal risk compared...
Phrenic Nerve Paralysis as the Initial Presentation of Granulomatosis with Polyangiitis
Hamid Feiz, Elana Oberstein, Natalya Lyubynska, Shalini Kulkarni* and Fulvia Banu
Genetic Factors Involved in the Pathogenesis of Systemic Lupus Erythematosus
Yo Kodera1, Mareki Ohtsuji1, Toshikazu Shirai2, Sachiko Hirose2 and Hiroyuki Nishimura1*
Systemic Lupus Erythematosus (SLE) is a typical systemic autoimmune disease characterized by the production of auto antibodies reactive to nuclear and cellular components such as double-stranded DNA, RNA-p...
Generalized Pustular Psoriasis: a New Emerging Concept Relating to Autoinflammatory Disease
Yamamoto T
Protein kinase Inhibitors for the Treatment of Inflammatory and Autoimmune Diseases
Alexandros Grammatikos
Environmental Factors Involved in the Pathogenesis of Systemic Lupus Erythematosus
Hiroshi Okamoto
Systemic Lupus Erythematosus (SLE) is an autoimmune disease that predominantly affects women and is characterized by widespread immunologic abnormalities. The disease involves multiple organs including the...
No Differences in Number and Distribution of Dermal Mast Cells between Acute and Chronic Cutaneous Lupus Erythematosus
Mikiko Uede1, Yasushi Nakamura2, Yuki Yamamoto1 and Fukumi Furukawa1*
The appearance of mast cells at eruption sites was examined in acute (ACLE) and chronic (CCLE) cutaneous Lupus Erythematosus (LE). As shown by toluidine blue staining and c-kit immunostaining, mast cells w...
Celiac Disease: A Brief Review of Current Literature
Farah Khalifeh* and Hamzeh M. Halawani1
Effects of Cissampelos sympodialis Extract in a Murine Model of Streptozotocin-Induced Diabetes
Ana Tereza Cerqueira Lima1, Laise Cedraz Pinto1, Tatiane Oliveira Teixeira1, Samara dos Santos Suzarth1, Keina Maciele Campos Dourado1, Karina Carla de Paula Medeiros2, Márcia Regina Piuvezam3, Lain Carlos Pontes de Carvalho4, Neuza Maria Alcantara-Neves1 and Camila A Figueiredo1*
Cissampelos sympodialis (Cs) is an herb used for the treatment of several diseases due to its anti-inflammatory properties. The present study investigated the effect of oral administration of Cs extract on...
Current Management of Type 1 Autoimmune Pancreatitis: From the Viewpoint of Pancreatic Endocrine and Exocrine Function
Lingaku Lee1, Tetsuhide Ito1*, Masayuki Hijioka1, Hisato Igarashi1, Keijiro Ueda1, Takashi Fujiyama1, Yuichi Tachibana1, Ken Kawabe1, Robert T Jensen2, Kazuhiko Nakamura1, Masaki Kato1, Koichi Suzuki3 and Ryoichi Takayanagi1
Autoimmune Pancreatitis (AIP) is a pancreatic inflammatory disease caused by an autoimmune mechanism. Histologically, two subtypes exist: type 1 characterized by lymphoplasmacytic sclerosing pancreatitis&n...
Transient Elastography for Detecting Liver Fibrosis in Methotrexate-Treated Patients with Inflammatory Disorders: A Systematic Review
A Wilson1, P Basharat2*, M Levstik3 and L Barra4
Objective: Methotrexate (MTX) is used for the treatment of inflammatory disorders but can cause liver enzyme abnormalities. Liver enzyme elevations are neither specific nor sensitive for detecting liver fi...
Biological Therapeutics and Pharmacovigilance in Italy
Daria Cipollone1, Rita Businaro1, Pasquale Ricci2, Emanuela Onofri2, Francesco Massoni2, Gabriella Azzara2, Max Rapp-Ricciardi3,Trevor Archer1* and Serafino Ricci2
Biological Therapeutics (BTs) present a novel frontier for the treatment of autoimmune diseases, such as rheumatoid arthritis, psoriasis, Crohn's disease and several other conditions. BTs constitute h...
High Frequency of Vitamin D Deficiency in Patients with Rheumatoid Arthritis
Hideyuki Watanabe1, Nobuhisa Hirase1, Hideaki Goda1, Akie Hirata2, Hiroshi Nishikawa1, Yoshiyuki Arita1 and Shoichiro Ikuyama1*
Objectives: Vitamin D (VD) has multiple physiological function including bone-mineral metabolism and musculo-skeletal effects. The purpose of this study is to disclose actual circumstances of VD contentmen...