Rheumatoid Arthritis (RA) as a chronic progressive 
systemic autoimmune disease with hallmark of chronic erosive 
polyarthritis is the most common inflammatory articular disorder. 
Its overall prevalence is 1% and it is more common in middle to old 
aged women. Arthritis of peripheral synovial joints can be seen in 
almost all patients with RA. Chronic symmetric oligo/polyarthritis 
with especially small joints involvement of hand along with 
prolonged morning stiffness is the predominant feature of RA. 
Extra-articular manifestations of RA usually can not be seen within 
initial presentation of it. High titer RF or Anti-CCP and both RF 
and Anti-CCP positivity are serologic hallmarks of disease.  
Erosion is imaging hallmark of RA that can be detected in MRI 
much earlier than in plain X-Ray of involved joint. Positive family 
history of RA and HLA-DR4 positivity are associated with higher 
risk of future RA. Smoking is the most important environmental 
factor for development of RA. The 1987 ACR criteria and the 2010 
ACR/EULAR criteria for RA ;both are designed for classification 
of RA but the Iran criteria for RA (2011) can be used for early 
diagnosis of RA with clinical synovitis during the acute to early 
chronic phase of disease. The corresponding-author of this letter 
wants to deliver a new criteria called “2016 ACR/EULAR revised 
criteria for too early diagnosis of RA”in the first week of initiation 
of RA especially subclinical cases. 
 
Keywords: ACR Criteria; ACR/EULAR Criteria; IRAN Criteria; 
Criteria