Development of Heart Failure (HF) associates with 
endothelial dysfunction that considered a key cause for 
tissue injury, and target organ damage. Endothelial 
Microparticles (EMPs) are small membrane vesicles that 
originate from activated or apoptotic endothelial cells and 
play a pivotal role in cell-to-cell communication, cellular 
fusion, and transport of biological active molecules. EMPs 
contribute in different types of biological effects depending 
on their origin. EMPs derived from activated endothelial 
cells may mediate tissue and vascular repair; induce 
angiogenesis, neovascularization, and cell differentiation. 
EMPs originated from apoptotic particles support 
inflammation,
 oxidative 
injury,
 reprogramming, 
intercellular communication of the target cells. Balance 
between both phenotypes of microparticles in circulation is 
frequently mediated by HF stage, aging, as well as 
comorbidity states. The review is depicted the role of 
several phenotypes of EMPs in realize of comorbidity state 
effects on endothelial function among HF patients.