The recognition of the importance of overweigh / obesity 
and metabolic syndrome as leading risk factor for diabetes and 
cardiovascular (CV) complications has greatly increased within 
last decades. Endothelial dysfunction mediating the diabetic 
complications associates with several important mechanisms, one 
of which is secretion of extracellular microparticles (MPs) by 
activated or apoptotic endothelial cells. MPs coordinate wide 
spectrum 
biological 
processes, 
i.e. 
angiogenesis, 
neovascularization, cell growth / differentiation, proliferation, 
coagulation, and they are involved in the epigenetic regulation of 
post-processing that is essential for phenotype modification, tissue 
repair, cell death, malignancy, and immunity. The commentary is 
discussed the role of impaired balance between number of both 
immune subsets of endothelial MPs in CV events development 
among dysmetabolic subjects. It has revealed that increased 
numbers of apoptotic MPs, as well as decreased numbers of MPs 
derived from activated endothelial cells aggravate endothelial 
damage and contribute to the continuously deteriorating 
endothelial damage leading to diabetes-related complications.