Prostate cancer (PCa) is one of the most common 
malignant diseases in western world and now emerging as a 
challenging disease in developing countries. Although 
much progress has been done to control of androgen 
sensitive PCa in recent years, the early diagnosis and 
treatment for Prostate cancer are not yet satisfactory and, 
thus the metastatic progression control/treatment is still 
poor. MicroRNAs (miRNAs) are well known regulatory 
factor of physiological and developmental processes, it has 
been revealed that many miRNAs contribute the initiation 
and progression of various cancers. In the present 
preliminary study, we evaluated the expression status of 
miR-7-1-3p on normal prostate cell line (PNT1A), 
androgen sensitive prostate cancer cell line (LNCaP) and 
androgen insensitive prostate cancer cell lines (DU145). 
The results of this study revealed that miR-7-1-3p was up
regulated in metastatic form of prostate cancer cell line 
DU145, but no changes were noticed in miR-7 expression 
on other cell lines (LNCaP and PNT1A). Thus our 
preliminary studies suggested that miR-7-1-3p may serve 
as a novel microRNA for the diagnosis and as a new 
therapeutic target in prostate cancer.