Aims: To evaluate the utility of endoscopic obliterative therapy 
with n-butyl-2-cyanoacrylate (a tissue adhesive) for gastric 
varices and to assess the incidence of serious complications.  
Methods: Endoscopic obliterative therapy with n-butyl-2
cyanoacrylate was performed on two groups of patients with 
gastric varices. One group consisted of 129 patients from year 
1992 through 2000, and the second of 92 from 2001 through 
2014 (total=221).  Endoscopic therapy was performed under 
fluoroscopy using 70% cyanoacrylate diluted with 5% Lipiodol.  
Results: Endoscopic obliterative therapy with cyanoacrylate for 
gastric varices was successful in all 221 cases. The recurrence 
rate was 30/210 (14.3%) among patients wherre variceal 
eradication had been achieved. Additional treatment was 
successfully performed in all recurrent cases. The incidence of 
serious complications in the first group was 4/129 (3.1%), 
including two cases of splenic infarction, one of pulmonary 
embolism, and one of an inflammatory tumor of the pancreatic 
tail. In contrast, there were no serious complications was in the 
group treated later using smaller amounts of n-butyl-2
cyanoacrylate.  
Conclusions: Endoscopic obliterative therapy with 
cyanoacrylate is a useful and relatively safe method for treatment 
of bleeding gastric varices.  
Nonetheless, careful attention must be paid to the 
avoidance of potentially serious complications.  
Keywords: N-butyl-2-cyanoacrylate; Endoscopic Obliterative 
Therapy; Gastric Varices; Histoacryl®