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Autoimmune Diseases and Therapeutic Approaches

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Original Research Vol. 3, Issue 2 (2016)

Subclinical Behcet’s Disease

Iraj Salehi-Abari
Corresponding Author: Iraj Salehi-Abari
Received: Sep 30, 2016
Accepted: Oct 07, 2016
Published: Oct 10, 2016
Views: 11
DOI: N/A

Abstract

Behcet’s Disease (BD) is a chronic inflammatory multisystem disease belongs to the Vasculitidies with small, medium and large sized vessel involvement. This disorder is 
characterized by Oral aphthosis, Genital aphthosis, ocular inflammation, skin lesions, vascular involvement, positive Pathergy test and HLA-B51 positivity. When a patient is involved in Behcet’s Disease (BD) but his/her disease is presented as simple oral aphthosis and in which the pathergy test and/or HLA-B51 are positive but other clinical features are obscured; it is called subclinical BD. Two types of subclinical BD have been detected by the author yet; type I and type II. 

Subclinical BD type I is a varient of BD with the combination of: 
• Low frequent, minor, recurrent oral aphthosis 
• Occasionally a few pseudofolliculitis lesions and 
• The pathergy test and/or HLA-B51 positivity Subclinical BD type II is a varient of BD with the combination of: 
• Low frequent, minor, recurrent oral aphthosis 
• Recurrent internal genital (vaginal/cervical) aphthosis and 
• The pathergy test and/or HLA-B51 positivity Indeed some parts of the cases with simple oral aphthosis are the cases with missed subclinical BD. So, the author thinks that, the prevalence of BD may be underestimated. 
 
 
Keywords: Oral Aphthosis; Genital Aphthosis; HLA-B51 Positivity; Pathergy Test; Subclinical BD Type I and II

 

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Iraj Salehi-Abari (2016), Subclinical Behcet’s Disease. Autoimmune Dis Ther Approaches 3:124
Copyright: Copyright: © 2016 ADTAOA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Version 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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