The purpose of this work was to report a clinical case 
of a spayed, 13-year-old diabetic poodle on insulin therapy 
with insulin resistance and poor diabetes control secondary 
to severe periodontitis. Prior to establishing the periodontal 
surgical approach, the insulin dose needed to be increased 
to stabilize the patient. Periodontal treatment included the 
extraction of 19 teeth. After periodontitis treatment, the 
insulin dose could be reduced to the previous effective 
dose. To our knowledge, this is the first case report of 
insulin resistance due to periodontal disease in dogs.