Aim: Potassium inwardly rectifying channel, subfamily J, 
member 11 (KCNJ11) gene has a key role in insulin secretion and 
is of substantial interest as a candidate gene for Type 2 
Diabetes (T2D). The current work was performed to delineate 
the genetic influence of the most associated SNP of KCNJ11 gene 
E23K (rs5219) polymorphism on risk of T2D in Indian population 
of eastern Uttar Pradesh through case-control association study. 
Method: A case-control study of 240 T2D cases and 229 controls 
was performed using the Polymerase Chain Reaction-Restriction 
Fragment Length Polymorphism (PCR-RFLP) approach to 
analyze the association of KCNJ11 E23K (rs5219) polymorphism 
on the risk of T2D. Odds ratio with 95% Confidence Interval (CI) 
was used to assess the association strength.  
Result: Type 2 diabetes patients studied for the gene had 
significantly higher levels of Fasting Plasma Glucose (FPG) and 2 
hr PPPG (P<5 x 10-2) than healthy controls. The genetic variants 
of loci show Hardy-Weinberg distributions in our study. The 
genotype and allele distributions of polymorphism are 
significantly different between the T2D patients and healthy 
control groups. Our data show weak association to T2D with odds 
ratio 1.086 (95% CI 0.832-1.416; P = 0.544).  
Conclusion: Our data provides valuable information for 
comparison with other ethnic groups as well as in determining 
disease susceptibility in Indian population of eastern Uttar 
Pradesh. However, in view of the genetic diversity of Indians, the 
result needs to be replicated in other groups. Interestingly, our 
data for the SNP show small effect size than those reported in 
European and East Asian populations; and North-Western Indian 
populations.