Neurological Research and Therapy
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The Role of Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis
Dimitri Falco1, David Eve1,2, Avery Thomson1 and Svitlana Garbuzova-Davis1-4*
Astrocytes are glial cells that play a crucial role in providing a supportive environment for neurons, mainly by cellcell interactions mediating numerous physiological and biochemical functions in the cent...
The Role of Matrix Metalloproteinases in Neurovascular Unit Integrity in Amyotrophic Lateral Sclerosis
Artyom Vlasenko1* and Svitlana Garbuzova-Davis1-4
Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative and neurovascular disorder with multi-factorial molecular mechanisms of pathology. At the very core of B-CNSB alterations associated with ...
Differentiation between Complex Tic and Eyelid Myoclonia with Absences: Pediatric Case Report and Brief Review of the Literature
Diana M Gerardi1, Caroline De Oleo Brozyna2, S Parrish Winesett3, 4, Maria Gieron Korthals1, 3 and Tanya Murphy1, 2*
Eyelid Myoclonia with Absences (EMA) can often be clinically mistaken for a tic disorder. This case report describes a 4-year-old female who presented with eye fluttering and blinking accompanied by a hand...
Physical Therapy Management of a Patient with Severe Ataxia and Imbalance Secondary to Herpes Simplex Encephalitis
Hannah E Zajac1 and Anne D Kloos2*
Background and Purpose: Herpes Simplex Encephalitis (HSE), the most common cause of sporadic viral encephalitis, causes permanent neurologic deficits and disablement in many affected individuals. To our&nb...
Alleviating Symptoms of Attention Deficit Hyperactive Disorder Using Bal-A-Vis-X, a Non-Pharmacological Approach.
Dixon Chibanda1
Approved pharmacological preparations for the treatment of Attention Deficit Hyperactive Disorder (ADHD) are not readily available in most low and middle-income countries. There is a growing body of altern...
Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Joy Mitra1, Velmarini Vasquez1,5,6, Pavana M Hegde1, Istvan Boldogh7, Sankar Mitra1,3,4, Thomas A Kent8, Kosagi S Rao5, and Muralidhar L Hegde1,2,3,4*
Healthcare Utilization in Patients with Uncontrolled Epilepsy: A Retrospective Study in a Commercially-Insured U.S. Population
Fulton Velez*1, Vamsi Bollu1, Thirupathi Pattipaka2 and Maria Malmenäs2
Objective: To evaluate the healthcare and societal economic burden of adjunctively-treated patients with uncontrolled epilepsy. Methods: A retrospective claims database (representative of the commerci...
Transcranial Magnetic Stimulation for Restless Legs Syndrome: Probing the Neurophysiological Basis towards a Novel Therapeutic Tool?
Giuseppe Lanza* and Raffaele Ferri
Intramedullary Tuberculoma Concomitant with Intracerebral Disseminated Tuberculoma
Hiren N Patel1* and Douglas L Stofko2
Disseminated tuberculosis to the brain and spine may present before typical tuberculosis systemic symptoms manifest. We present a case where a patient presented with progressive paraplegia and change in me...
Triptan Is Effective for the Migraine with Aura-Like Headache Associated With Moyamoya Disease
Koichi Hirata1, Akinori Hozumi1, Akio Iwasaki1, Yuji Watanabe1, Eisei Hoshiyama1 and Fumihiko Sakai2*
We describe two cases of moyamoya disease associated with headache which had been diagnosed as migraine with aura meeting the International Headache Society criteria. Administration of triptan was clinical...
Effects of PNF Method for Hemiplegic Patients with Brachial Predominance after Stroke: Controlled and Blinded Clinical Trial
Karen Rocha De Moraes, Evelim Leal De Freitas*, Dantas Gomes, Samantha Souza Possa and Luciana Barcala
In stroke, ninety percent of survivors have motor sequelae, being the main one is hemiplegia or hemi paresis, respectively defined as total or partial paralysis of the movements of one side of the body, in...